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Carbapenemase Genes among Multidrug Resistant Gram Negative Clinical Isolates from a Tertiary Hospital in Mwanza, Tanzania
Joint Authors
Mshana, Stephen E.
Mushi, Martha F.
Bwanga, Freddie
Imirzalioglu, Can
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The burden of antimicrobial resistance (AMR) is rapidly growing across antibiotic classes, with increased detection of isolates resistant to carbapenems.
Data on the prevalence of carbapenem resistance in developing countries is limited; therefore, in this study, we determined the prevalence of carbapenemase genes among multidrug resistant gram negative bacteria (MDR-GNB) isolated from clinical specimens in a tertiary hospital in Mwanza, Tanzania.
A total of 227 MDR-GNB isolates were analyzed for carbapenem resistance genes.
For each isolate, five different PCR assays were performed, allowing for the detection of the major carbapenemase genes, including those encoding the VIM-, IMP-, and NDM-type metallo-beta-lactamases, the class A KPC-type carbapenemases, and the class D OXA-48 enzyme.
Of 227 isolates, 80 (35%) were positive for one or more carbapenemase gene.
IMP-types were the most predominant gene followed by VIM, in 49 (21.59%) and 28 (12%) isolates, respectively.
Carbapenemase genes were most detected in K.
pneumoniae 24 (11%), followed by P.
aeruginosa 23 (10%), and E.
coli with 19 isolates (8%).
We have demonstrated for the first time a high prevalence of MDR-GNB clinical isolates having carbapenem resistance genes in Tanzania.
We recommend routine testing for carbapenem resistance among the MDR-GNB particularly in systemic infections.
American Psychological Association (APA)
Mushi, Martha F.& Mshana, Stephen E.& Imirzalioglu, Can& Bwanga, Freddie. 2014. Carbapenemase Genes among Multidrug Resistant Gram Negative Clinical Isolates from a Tertiary Hospital in Mwanza, Tanzania. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-461761
Modern Language Association (MLA)
Mushi, Martha F.…[et al.]. Carbapenemase Genes among Multidrug Resistant Gram Negative Clinical Isolates from a Tertiary Hospital in Mwanza, Tanzania. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-461761
American Medical Association (AMA)
Mushi, Martha F.& Mshana, Stephen E.& Imirzalioglu, Can& Bwanga, Freddie. Carbapenemase Genes among Multidrug Resistant Gram Negative Clinical Isolates from a Tertiary Hospital in Mwanza, Tanzania. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-461761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461761