Identification of Women for Referral to Colposcopy by Neural Networks : A Preliminary Study Based on LBC and Molecular Biomarkers
Joint Authors
Koliopoulos, George
Karakitsos, Petros
Meristoudis, Christos
Kyrgiou, Maria
Panayiotides, Ioannis
Paraskevaidis, Evangelos A.
Pouliakis, Abraham
Chranioti, Aikaterini
Kottaridi, Christine
Valasoulis, George
Spathis, Aris
Chrelias, Charalampos
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective of this study is to investigate the potential of the learning vector quantizer neural network (LVQ-NN) classifier on various diagnostic variables used in the modern cytopathology laboratory and to build an algorithm that may facilitate the classification of individual cases.
From all women included in the study, a liquid-based cytology sample was obtained; this was tested via HPV DNA test, E6/E7 HPV mRNA test, and p16 immunostaining.
The data were classified by the LVQ-NN into two groups: CIN-2 or worse and CIN-1 or less.
Half of the cases were used to train the LVQ-NN; the remaining cases (test set) were used for validation.
Out of the 1258 cases, cytology identified correctly 72.90% of the CIN-2 or worst cases and 97.37% of the CIN-1 or less cases, with overall accuracy 94.36%.
The application of the LVQ-NN on the test set allowed correct classification for 84.62% of the cases with CIN-2 or worse and 97.64% of the cases with CIN-1 or less, with overall accuracy of 96.03%.
The use of the LVQ-NN with cytology and the proposed biomarkers improves significantly the correct classification of cervical precancerous lesions and/or cancer and may facilitate diagnosis and patient management.
American Psychological Association (APA)
Karakitsos, Petros& Chrelias, Charalampos& Pouliakis, Abraham& Koliopoulos, George& Spathis, Aris& Kyrgiou, Maria…[et al.]. 2012. Identification of Women for Referral to Colposcopy by Neural Networks : A Preliminary Study Based on LBC and Molecular Biomarkers. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461772
Modern Language Association (MLA)
Karakitsos, Petros…[et al.]. Identification of Women for Referral to Colposcopy by Neural Networks : A Preliminary Study Based on LBC and Molecular Biomarkers. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-461772
American Medical Association (AMA)
Karakitsos, Petros& Chrelias, Charalampos& Pouliakis, Abraham& Koliopoulos, George& Spathis, Aris& Kyrgiou, Maria…[et al.]. Identification of Women for Referral to Colposcopy by Neural Networks : A Preliminary Study Based on LBC and Molecular Biomarkers. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461772