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The Role of Long-Chained Marine N-3 Polyunsaturated Fatty Acids in Cardiovascular Disease
Joint Authors
Grundt, Heidi
Nilsen, Dennis W. T.
Nygård, Ottar Kjell
Aarsetoey, Hildegunn
Source
Cardiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-13
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
This paper reviews the current evidence regarding long-chained marine omega-3 polyunsaturated fatty acids (PUFAs) and cardiovascular disease (CVD), their possible mechanisms of action, and results of clinical trials.
Also, primary and secondary prevention trials as studies on antiarrhythmic effects and meta-analyses are summarized.
However, the individual bioavailability of n-3 PUFAs along with the highly different study designs and estimations of FAs intake or supplementation dosages in patient populations with different background intake of n-3 PUFAs might be some of the reasons for the inconsistent findings of the studies evaluating the impact of n-3 PUFAs on CVD.
The question of an optimum dose of n-3 PUFAs or whether there exists a dose-response relation for n-3 PUFA supplementation is widely discussed.
Moreover, the difficulties in interpreting meta-analyses are clearly demonstrated by two recently published meta-analyses (Rizos et al.
and Delgado Lista et al.), evaluating the efficacy of n-3 PUFAs on CVD, including 12 common studies, but drawing opposite conclusions.
We definitely need more large-scale, randomized clinical trials of long duration, also reporting harmful effects of n-3 PUFAs.
American Psychological Association (APA)
Aarsetoey, Hildegunn& Grundt, Heidi& Nygård, Ottar Kjell& Nilsen, Dennis W. T.. 2012. The Role of Long-Chained Marine N-3 Polyunsaturated Fatty Acids in Cardiovascular Disease. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-461782
Modern Language Association (MLA)
Aarsetoey, Hildegunn…[et al.]. The Role of Long-Chained Marine N-3 Polyunsaturated Fatty Acids in Cardiovascular Disease. Cardiology Research and Practice No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-461782
American Medical Association (AMA)
Aarsetoey, Hildegunn& Grundt, Heidi& Nygård, Ottar Kjell& Nilsen, Dennis W. T.. The Role of Long-Chained Marine N-3 Polyunsaturated Fatty Acids in Cardiovascular Disease. Cardiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-461782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461782