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Is IgG4-Related Disease a Cause of Xerostomia? A Cohort Study of 60 Patients
Joint Authors
Hermet, M.
Aumaître, O.
Tridon, Arlette
Delèvaux, I.
Le Guenno, G.
Dechelotte, Pierre
Guettrot-Imbert, G.
Kémény, J. L.
André, M.
Soubrier, Martin
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Immunoglobulin-G4-(IgG4-) related disease (IgG4 RD) is a fibrosing process characterized by a significant infiltration of IgG4-secreting plasma cells.
IgG4 RD can affect almost all organs including salivary glands.
Whether IgG4 RD plays a role in the development of sicca syndrome and particularly dry mouth syndrome remains to be investigated.
Methods.
We conducted a monocentric cohort study for two years to search for IgG4 RD features in patients with dry mouth syndrome using immunostainings of labial salivary gland specimens with anti-IgG4 antibody.
Results.
Among 60 patients presenting with dry mouth syndrome who underwent labial salivary gland biopsy, 18 showed positive immunostaining with the anti-IgG4 antibody including 4 patients with typical systemic IgG4 RD.
Five also fulfilled criteria for Sjögren's syndrome.
Conclusion.
These findings suggest that clinical forms of IgG4 RD salivary involvement without salivary swelling may occur.
This salivary involvement is probably overlooked in everyday practice and could represent a mild form of IgG4 RD.
American Psychological Association (APA)
Hermet, M.& André, M.& Kémény, J. L.& Le Guenno, G.& Dechelotte, Pierre& Guettrot-Imbert, G.…[et al.]. 2012. Is IgG4-Related Disease a Cause of Xerostomia? A Cohort Study of 60 Patients. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-461789
Modern Language Association (MLA)
Hermet, M.…[et al.]. Is IgG4-Related Disease a Cause of Xerostomia? A Cohort Study of 60 Patients. International Journal of Rheumatology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-461789
American Medical Association (AMA)
Hermet, M.& André, M.& Kémény, J. L.& Le Guenno, G.& Dechelotte, Pierre& Guettrot-Imbert, G.…[et al.]. Is IgG4-Related Disease a Cause of Xerostomia? A Cohort Study of 60 Patients. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-461789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461789