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Plasma Total Cysteine and Cardiovascular Risk Burden : Action and Interaction
Joint Authors
De Maria, Renata
De Chiara, Benedetta
Corno, Anna Rosa
Parolini, Marina
Parodi, Oberdan
Sedda, Valentina
Pizzi, Gianluigi
Disoteo, Olga
Cighetti, Giuliana
Campolo, Jonica
Dellanoce, Cinzia
Caruso, Raffaele
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
We hypothesized that redox analysis could provide sensitive markers of the oxidative pathway associated to the presence of an increasing number of cardiovascular risk factors (RFs), independently of type.
We classified 304 subjects without cardiovascular disease into 4 groups according to the total number of RFs (smoking, hypertension, hypercholesterolaemia, hyperhomocysteinaemia, diabetes, obesity, and their combination).
Oxidative stress was evaluated by measuring plasma total and reduced homocysteine, cysteine (Cys), glutathione, cysteinylglycine, blood reduced glutathione, and malondialdehyde.
Twenty-seven percent of subjects were in group 0 RF, 26% in 1 RF, 31% in 2 RF, and 16% in ≥3 RF.
By multivariable ordinal regression analysis, plasma total Cys was associated to a higher number of RF (OR = 1.068; 95% CI = 1.027–1.110, P=0.002).
Total RF burden is associated with increased total Cys levels.
These findings support a prooxidant effect of Cys in conjunction with RF burden, and shed light on the pathophysiologic role of redox state unbalance in preclinical atherosclerosis.
American Psychological Association (APA)
De Chiara, Benedetta& Sedda, Valentina& Parolini, Marina& Campolo, Jonica& De Maria, Renata& Caruso, Raffaele…[et al.]. 2012. Plasma Total Cysteine and Cardiovascular Risk Burden : Action and Interaction. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-461804
Modern Language Association (MLA)
De Chiara, Benedetta…[et al.]. Plasma Total Cysteine and Cardiovascular Risk Burden : Action and Interaction. The Scientific World Journal No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-461804
American Medical Association (AMA)
De Chiara, Benedetta& Sedda, Valentina& Parolini, Marina& Campolo, Jonica& De Maria, Renata& Caruso, Raffaele…[et al.]. Plasma Total Cysteine and Cardiovascular Risk Burden : Action and Interaction. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-461804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461804