Chitosan-Based Macromolecular Biomaterials for the Regeneration of Chondroskeletal and Nerve Tissue
Joint Authors
Rosellini, Elisabetta
Barbani, Niccoletta
Cristallini, Caterina
Gagliardi, Mariacristina
Guerra, Giulio D.
Source
International Journal of Carbohydrate Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The use of materials, containing the biocompatible and bioresorbable biopolymer poly(1→4)-2-amino-2-deoxy-β-D-glucan, containing some N-acetyl-glucosamine units (chitosan, CHI) and/or its derivatives, to fabricate devices for the regeneration of bone, cartilage and nerve tissue, was reviewed.
The CHI-containing devices, to be used for bone and cartilage regeneration and healing, were tested mainly for in vitro cell adhesion and proliferation and for insertion into animals; only the use of CHI in dental surgery has reached the clinical application.
Regarding the nerve tissue, only a surgical repair of a 35 mm-long nerve defect in the median nerve of the right arm at elbow level with an artificial nerve graft, comprising an outer microporous conduit of CHI and internal oriented filaments of poly(glycolic acid), was reported.
As a consequence, although many positive results have been obtained, much work must still be made, especially for the passage from the experimentation of the CHI-based devices, in vitro and in animals, to their clinical application.
American Psychological Association (APA)
Guerra, Giulio D.& Barbani, Niccoletta& Gagliardi, Mariacristina& Rosellini, Elisabetta& Cristallini, Caterina. 2011. Chitosan-Based Macromolecular Biomaterials for the Regeneration of Chondroskeletal and Nerve Tissue. International Journal of Carbohydrate Chemistry،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-461809
Modern Language Association (MLA)
Guerra, Giulio D.…[et al.]. Chitosan-Based Macromolecular Biomaterials for the Regeneration of Chondroskeletal and Nerve Tissue. International Journal of Carbohydrate Chemistry No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-461809
American Medical Association (AMA)
Guerra, Giulio D.& Barbani, Niccoletta& Gagliardi, Mariacristina& Rosellini, Elisabetta& Cristallini, Caterina. Chitosan-Based Macromolecular Biomaterials for the Regeneration of Chondroskeletal and Nerve Tissue. International Journal of Carbohydrate Chemistry. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-461809
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461809