Robust Design of Biological Circuits : Evolutionary Systems Biology Approach
Joint Authors
Chen, Bor-Sen
Liou, Jing-Jia
Hsu, Chih-Yuan
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-07
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Artificial gene circuits have been proposed to be embedded into microbial cells that function as switches, timers, oscillators, and the Boolean logic gates.
Building more complex systems from these basic gene circuit components is one key advance for biologic circuit design and synthetic biology.
However, the behavior of bioengineered gene circuits remains unstable and uncertain.
In this study, a nonlinear stochastic system is proposed to model the biological systems with intrinsic parameter fluctuations and environmental molecular noise from the cellular context in the host cell.
Based on evolutionary systems biology algorithm, the design parameters of target gene circuits can evolve to specific values in order to robustly track a desired biologic function in spite of intrinsic and environmental noise.
The fitness function is selected to be inversely proportional to the tracking error so that the evolutionary biological circuit can achieve the optimal tracking mimicking the evolutionary process of a gene circuit.
Finally, several design examples are given in silico with the Monte Carlo simulation to illustrate the design procedure and to confirm the robust performance of the proposed design method.
The result shows that the designed gene circuits can robustly track desired behaviors with minimal errors even with nontrivial intrinsic and external noise.
American Psychological Association (APA)
Chen, Bor-Sen& Hsu, Chih-Yuan& Liou, Jing-Jia. 2011. Robust Design of Biological Circuits : Evolutionary Systems Biology Approach. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-461849
Modern Language Association (MLA)
Chen, Bor-Sen…[et al.]. Robust Design of Biological Circuits : Evolutionary Systems Biology Approach. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-461849
American Medical Association (AMA)
Chen, Bor-Sen& Hsu, Chih-Yuan& Liou, Jing-Jia. Robust Design of Biological Circuits : Evolutionary Systems Biology Approach. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-461849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461849