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A Pleiotropic Role for the Orphan Nuclear Receptor Small Heterodimer Partner in Lipid Homeostasis and Metabolic Pathways
Joint Authors
Bonfrate, Leonilde
Wang, David Q.-H.
Garruti, Gabriella
de Bari, Ornella
Wang, Helen H.
Portincasa, Piero
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-22
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Nuclear receptors (NRs) comprise one of the most abundant classes of transcriptional regulators of metabolic diseases and have emerged as promising pharmaceutical targets.
Small heterodimer partner (SHP; NR0B2) is a unique orphan NR lacking a DNA-binding domain but contains a putative ligand-binding domain.
SHP is a transcriptional regulator affecting multiple key biological functions and metabolic processes including cholesterol, bile acid, and fatty acid metabolism, as well as reproductive biology and glucose-energy homeostasis.
About half of all mammalian NRs and several transcriptional coregulators can interact with SHP.
The SHP-mediated repression of target transcription factors includes at least three mechanisms including direct interference with the C-terminal activation function 2 (AF2) coactivator domains of NRs, recruitment of corepressors, or direct interaction with the surface of NR/transcription factors.
Future research must focus on synthetic ligands acting on SHP as a potential therapeutic target in a series of metabolic abnormalities.
Current understanding about the pleiotropic role of SHP is examined in this paper, and principal metabolic aspects connected with SHP function will be also discussed.
American Psychological Association (APA)
Garruti, Gabriella& Wang, Helen H.& Bonfrate, Leonilde& de Bari, Ornella& Wang, David Q.-H.& Portincasa, Piero. 2012. A Pleiotropic Role for the Orphan Nuclear Receptor Small Heterodimer Partner in Lipid Homeostasis and Metabolic Pathways. Journal of Lipids،Vol. 2012, no. 2012, pp.1-22.
https://search.emarefa.net/detail/BIM-461852
Modern Language Association (MLA)
Garruti, Gabriella…[et al.]. A Pleiotropic Role for the Orphan Nuclear Receptor Small Heterodimer Partner in Lipid Homeostasis and Metabolic Pathways. Journal of Lipids No. 2012 (2012), pp.1-22.
https://search.emarefa.net/detail/BIM-461852
American Medical Association (AMA)
Garruti, Gabriella& Wang, Helen H.& Bonfrate, Leonilde& de Bari, Ornella& Wang, David Q.-H.& Portincasa, Piero. A Pleiotropic Role for the Orphan Nuclear Receptor Small Heterodimer Partner in Lipid Homeostasis and Metabolic Pathways. Journal of Lipids. 2012. Vol. 2012, no. 2012, pp.1-22.
https://search.emarefa.net/detail/BIM-461852
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461852