Unusual T-Lymphoblastic Blast Phase of Chronic Myelogenous Leukemia
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
T-lymphoblastic leukemia/lymphoma (T-ALL) presenting as blast phase of chronic myelogenous leukemia (CML-BP) is rare.
In patients without history of CML, it is difficult to differentiate between CML-BP or de novo T-ALL.
Here we reported 2 unusual cases of T-ALL presenting as CML-BP.
Case 1 was a 24-year-old female with leukocytosis.
Besides T-lymphoblasts (32%), her marrow exhibited some morphologic features of CML.
Multiple remission or relapsing marrow had never demonstrated morphologic features of CML.
Despite of imatinib treatment and stem cell transplant, she died 2.5 years later.
Case 2, a 66-year-old male with diffuse lymphadenopathy, showed T-ALL in a lymph node and concurrent CML chronic phase (CML-CP) in his marrow.
Same BCR-ABL1 fusion transcript with minor breakpoint was present in both the lymph node and marrow specimens.
Although both cases did not have a history of CML, both cases represented T-lymphoblastic CML-BP with unusual features: Case 1 is unusual in that it presented as T-ALL with some CML morphologic feature but never showed CML-CP in her subsequent marrows biopsies; Case 2 is the first reported case of T-lymphoblastic CML-BP harboring BCR-ABL1 transcript with a minor breakpoint.
American Psychological Association (APA)
Xu, Jie& Li, Shaoying. 2014. Unusual T-Lymphoblastic Blast Phase of Chronic Myelogenous Leukemia. Case Reports in Hematology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-461862
Modern Language Association (MLA)
Xu, Jie& Li, Shaoying. Unusual T-Lymphoblastic Blast Phase of Chronic Myelogenous Leukemia. Case Reports in Hematology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-461862
American Medical Association (AMA)
Xu, Jie& Li, Shaoying. Unusual T-Lymphoblastic Blast Phase of Chronic Myelogenous Leukemia. Case Reports in Hematology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-461862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461862