Evaluation of Serum 25-Hydroxyvitamin D as a Predictor of Carotid Intima-Media Thickness and Carotid Total Plaque Area in Nonsmokers : The Tromsø Study
Joint Authors
Kamycheva, Elena
Jorde, Rolf
Johnsen, Stein Harald
Wilsgaard, Tom
Mathiesen, Ellisiv B.
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Altered calcium homeostasis has been linked to increased intima-media thickness (IMT) and plaques.
We aimed to investigate whether serum 25-hydroxyvitamin D (25(OH)D) and serum calcium are associated with IMT and plaques in nonsmoking population.
Methods.
Ultrasound of the right carotid artery with the measurements of IMT and plaques was performed in 4194 nonsmoking subjects with available measurements of serum 25(OH)D and total calcium.
Linear regression was applied to study the linear relationships between variables.
Multinomial logistic regression was used to evaluate predictors of increased IMT and total plaque area (TPA), adjusted for age, body mass index, systolic blood pressure, and total cholesterol.
Results.
There was no significant linear relationship between mean IMT, TPA, and either serum 25(OH)D or total serum calcium.
One SD increase in serum 25(OH)D was independently associated with increased odds of being in the highest quartile of IMT in men (OR 1.30, 95% CI 1.12, 1.51).
In women, 1 SD increase in serum 25(OH)D was independently associated with increased risk of being in the upper tertile of TPA (OR 1.15, 95% CI 1.01, 1.33).
Conclusions.
Impaired calcium homeostasis has no consistent association with mean IMT and TPA; however, increased serum 25(OH)D may predict subclinical atherosclerosis in nonsmokers.
American Psychological Association (APA)
Kamycheva, Elena& Johnsen, Stein Harald& Wilsgaard, Tom& Jorde, Rolf& Mathiesen, Ellisiv B.. 2013. Evaluation of Serum 25-Hydroxyvitamin D as a Predictor of Carotid Intima-Media Thickness and Carotid Total Plaque Area in Nonsmokers : The Tromsø Study. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-461921
Modern Language Association (MLA)
Kamycheva, Elena…[et al.]. Evaluation of Serum 25-Hydroxyvitamin D as a Predictor of Carotid Intima-Media Thickness and Carotid Total Plaque Area in Nonsmokers : The Tromsø Study. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-461921
American Medical Association (AMA)
Kamycheva, Elena& Johnsen, Stein Harald& Wilsgaard, Tom& Jorde, Rolf& Mathiesen, Ellisiv B.. Evaluation of Serum 25-Hydroxyvitamin D as a Predictor of Carotid Intima-Media Thickness and Carotid Total Plaque Area in Nonsmokers : The Tromsø Study. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-461921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461921