Mathematical Behavior of MEFV Curves in Childhood Asthma and the Role of Curvature in Quantifying Flow Obstruction
Joint Authors
Frey, Urs
Wildhaber, Johannes H.
Spycher, Ben
Sznitman, Josué
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Maximal expiratory flow-volume (MEFV) curves of pediatric patients are investigated using differentiation schemes and by computing their second derivative, d2V˙/dV2.
Results show that spirometric tracings illustrate a characteristic well-defined behavior, where two distinct regions of the MEFV curve may be identified: (1) a concave profile during the initial expiratory maneuver, and (2) a convex profile over the greater lower region of the descending phase of the MEFV curve; this latter region is characterized by an approximately constant positive value of d2V˙/dV2 such that the descending MEFV limb may be captured by a quadratic function.
Based on simple expiratory flow modeling, we show that d2V˙/dV2, and alternatively the local geometrical curvature κ(V), yield a measure of the relative degree of flow obstruction.
In view of future clinical applications, we make use of an “average curvature index”, to assist clinician’s assessment of asthma severity, by quantifying curvature and summarizing global information in MEFV curves.
American Psychological Association (APA)
Spycher, Ben& Frey, Urs& Wildhaber, Johannes H.& Sznitman, Josué. 2012. Mathematical Behavior of MEFV Curves in Childhood Asthma and the Role of Curvature in Quantifying Flow Obstruction. ISRN Pulmonology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-461924
Modern Language Association (MLA)
Spycher, Ben…[et al.]. Mathematical Behavior of MEFV Curves in Childhood Asthma and the Role of Curvature in Quantifying Flow Obstruction. ISRN Pulmonology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-461924
American Medical Association (AMA)
Spycher, Ben& Frey, Urs& Wildhaber, Johannes H.& Sznitman, Josué. Mathematical Behavior of MEFV Curves in Childhood Asthma and the Role of Curvature in Quantifying Flow Obstruction. ISRN Pulmonology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-461924
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461924