Angiotensin-Converting Enzyme Gene InsertionDeletion Polymorphism and Small Vessel Cerebral Stroke in Indian Population
Joint Authors
Prabhakar, Puttachandra
Nagaraja, Dindagur
De, Tanima
Christopher, Rita
Source
International Journal of Vascular Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Hypertension is an established risk factor for small-vessel cerebral stroke and the renin-angiotensin system plays an important role in the maintenance of blood pressure.
We aimed at evaluating the contribution of the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism to the risk of small-vessel stroke in south Indian population.
Materials and Methods.
We investigated 128 patients diagnosed with small-vessel stroke and 236 age, and gender-matched healthy controls.
ACE I/D polymorphism was detected by polymerase chain reaction.
Results.
Hypertension was significantly more prevalent in the patient group and was associated with 6-fold increase in risk for stroke.
ACE genotypes were in Hardy-Weinberg equilibrium in both patients and controls.
Prevalence of DD, ID, and II genotypes in cases (34.4%, 43.7%, and 28%) did not differ significantly from controls (31.8%, 43.2%, and 25%).
The polymorphism was not associated with small-vessel stroke (OR: 1.34; 95% CI: 0.52–1.55).
However, diastolic blood pressure was associated with the ACE I/D genotypes in the patients.
(DD; 90.2±14.2> ID; 86.2±11.9> II; 82.3±7.8 mm Hg, P=0.047).
Conclusion.
Our study showed that hypertension, but not ACE I/D polymorphism, increased the risk of small-vessel stroke.
American Psychological Association (APA)
Prabhakar, Puttachandra& De, Tanima& Nagaraja, Dindagur& Christopher, Rita. 2014. Angiotensin-Converting Enzyme Gene InsertionDeletion Polymorphism and Small Vessel Cerebral Stroke in Indian Population. International Journal of Vascular Medicine،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-461941
Modern Language Association (MLA)
Prabhakar, Puttachandra…[et al.]. Angiotensin-Converting Enzyme Gene InsertionDeletion Polymorphism and Small Vessel Cerebral Stroke in Indian Population. International Journal of Vascular Medicine No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-461941
American Medical Association (AMA)
Prabhakar, Puttachandra& De, Tanima& Nagaraja, Dindagur& Christopher, Rita. Angiotensin-Converting Enzyme Gene InsertionDeletion Polymorphism and Small Vessel Cerebral Stroke in Indian Population. International Journal of Vascular Medicine. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-461941
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461941