Mitochondria Are Related to Synaptic Pathology in Alzheimer's Disease
Author
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Morphological alterations of mitochondria may play an important role in the pathogenesis of Alzheimer's disease, been associated with oxidative stress and Aβ-peptide-induced toxicity.
We proceeded to estimation of mitochondria on electron micrographs of autopsy specimens of Alzheimer's disease.
We found substantial morphological and morphometric changes of the mitochondria in the neurons of the hippocampus, the neocortex, the cerebellar cortex, the thalamus, the globus pallidus, the red nucleus, the locus coeruleus, and the climbing fibers.
The alterations consisted of considerable changes of the cristae, accumulation of osmiophilic material, and modification of the shape and size.
Mitochondrial alterations were prominent in neurons, which showed a depletion of dendritic spines and loss of dendritic branches.
Mitochondrial alterations are not related with the accumulation of amyloid deposits, but are prominent whenever fragmentation of the Golgi apparatus exists.
Morphometric analysis showed also that mitochondria are significantly reduced in neurons, which demonstrated synaptic pathology.
American Psychological Association (APA)
Baloyannis, Stavros J.. 2011. Mitochondria Are Related to Synaptic Pathology in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-461947
Modern Language Association (MLA)
Baloyannis, Stavros J.. Mitochondria Are Related to Synaptic Pathology in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-461947
American Medical Association (AMA)
Baloyannis, Stavros J.. Mitochondria Are Related to Synaptic Pathology in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-461947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461947