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Evaluation of SLE Susceptibility Genes in Malaysians
Joint Authors
Kim-Howard, Xana
Chua, Kek Heng
Nath, Swapan K.
Lian, Lay Hoong
Molineros, Julio E.
Sun, Celi
Motghare, Prasenjeet
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Systemic Lupus Erythematosus (SLE) is a clinically heterogeneous autoimmune disease with strong genetic and environmental components.
Our objective was to replicate 25 recently identified SLE susceptibility genes in two distinct populations (Chinese (CH) and Malays (MA)) from Malaysia.
We genotyped 347 SLE cases and 356 controls (CH and MA) using the ImmunoChip array and performed an admixture corrected case-control association analysis.
Associated genes were grouped into five immune-related pathways.
While CH were largely homogenous, MA had three ancestry components (average 82.3% Asian, 14.5% European, and 3.2% African).
Ancestry proportions were significantly different between cases and controls in MA.
We identified 22 genes with at least one associated SNP (P<0.05).
The strongest signal was at HLA-DRA (PMeta=9.96×10-9; PCH=6.57×10-8, PMA=6.73×10-3); the strongest non-HLA signal occurred at STAT4 (PMeta=1.67×10-7; PCH=2.88×10-6, PMA=2.99×10-3).
Most of these genes were associated with B- and T-cell function and signaling pathways.
Our exploratory study using high-density fine-mapping suggests that most of the established SLE genes are also associated in the major ethnicities of Malaysia.
However, these novel SNPs showed stronger association in these Asian populations than with the SNPs reported in previous studies.
American Psychological Association (APA)
Molineros, Julio E.& Chua, Kek Heng& Sun, Celi& Lian, Lay Hoong& Motghare, Prasenjeet& Kim-Howard, Xana…[et al.]. 2014. Evaluation of SLE Susceptibility Genes in Malaysians. Autoimmune Diseases،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-461959
Modern Language Association (MLA)
Molineros, Julio E.…[et al.]. Evaluation of SLE Susceptibility Genes in Malaysians. Autoimmune Diseases No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-461959
American Medical Association (AMA)
Molineros, Julio E.& Chua, Kek Heng& Sun, Celi& Lian, Lay Hoong& Motghare, Prasenjeet& Kim-Howard, Xana…[et al.]. Evaluation of SLE Susceptibility Genes in Malaysians. Autoimmune Diseases. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-461959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461959