Effects of Stimulation and Blockade of D2 Receptor on Depression-Like Behavior in Ovariectomized Female Rats
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
The aim of the present study was to explore the hedonic effects of D2 receptor agonist, quinpirole and D2 receptor antagonist, and sulpiride alone or in combination with a low dose of 17β-E2-estradiol (17β-E2) in the adult ovariectomized female rats (OVX).
OVX rats of Wistar strain were used in all experiments.
Two weeks after surgery rats were chronically treated with vehicle, a low dose of 17β-E2 (5.0 μg/rat), quinpirole (0.1 mg/kg), sulpiride (10.0 mg/kg), quinpirole plus 17β-E2, or sulpiride plus 17β-E2 for 14 days before the forced swimming test.
We found that sulpiride significantly decreased immobility time in the OVX females.
A combination of sulpiride with a low dose of 17β-E2 induced more profound decrease of immobility time in the OVX rats compared to the rats treated with sulpiride alone.
On the contrary, quinpirole failed to modify depression-like behavior in the OVX rats.
In addition, quinpirole significantly blocked the antidepressant-like effect of 17β-E2 in OVX rats.
Thus, the D2 receptor antagonist sulpiride alone or in combination with a low dose of 17β-E2 exerted antidepressant-like effect in OVX female rats, while the D2 receptor agonist quinpirole produced depressant-like profile on OVX rats.
American Psychological Association (APA)
Fedotova, Julia. 2012. Effects of Stimulation and Blockade of D2 Receptor on Depression-Like Behavior in Ovariectomized Female Rats. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461972
Modern Language Association (MLA)
Fedotova, Julia. Effects of Stimulation and Blockade of D2 Receptor on Depression-Like Behavior in Ovariectomized Female Rats. ISRN Pharmacology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-461972
American Medical Association (AMA)
Fedotova, Julia. Effects of Stimulation and Blockade of D2 Receptor on Depression-Like Behavior in Ovariectomized Female Rats. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461972