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A Functional Polymorphism in B and T Lymphocyte Attenuator Is Associated with Susceptibility to Rheumatoid Arthritis
Joint Authors
Seto, Yohei
Ikeda, Kei
Iwamoto, Itsuo
Watanabe, Norihiko
Saito, Yasushi
Matsumura, Ryutaro
Nakajima, Hiroshi
Oya, Yoshihiro
Oki, Mie
Owada, Takayoshi
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Inhibitory coreceptors are thought to play important roles in maintaining immunological homeostasis, and a defect in the negative signals from inhibitory coreceptors may lead to the development of autoimmune diseases.
We have recently identified B and T lymphocyte attenuator (BTLA), a new inhibitory coreceptor expressed on immune cells, and we suggest that BTLA may be involved in the development of autoimmune diseases using BTLA-deficient mice.
However, the role of BTLA in the pathogenesis of autoimmune diseases in humans remains unknown.
We, therefore, examined the possible association between BTLA and rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjögren's syndrome (SS) by conducting a case-control genetic association study.
We found that 590C single-nucleotide polymorphism (SNP) of BTLA gene was significantly associated with susceptibility to RA, but not to SLE or SS.
Furthermore, RA patients bearing this 590C SNP developed the disease significantly earlier than the patients without this allele.
We also found that BTLA with 590C allele lacked the inhibitory activity on concanavalin A- and anti-CD3 Ab-induced IL-2 production in Jurkat T cells.
These results suggest that BTLA is an RA-susceptibility gene and is involved in the protection from autoimmunity in humans.
American Psychological Association (APA)
Oki, Mie& Watanabe, Norihiko& Owada, Takayoshi& Oya, Yoshihiro& Ikeda, Kei& Saito, Yasushi…[et al.]. 2011. A Functional Polymorphism in B and T Lymphocyte Attenuator Is Associated with Susceptibility to Rheumatoid Arthritis. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-461974
Modern Language Association (MLA)
Oki, Mie…[et al.]. A Functional Polymorphism in B and T Lymphocyte Attenuator Is Associated with Susceptibility to Rheumatoid Arthritis. Clinical and Developmental Immunology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-461974
American Medical Association (AMA)
Oki, Mie& Watanabe, Norihiko& Owada, Takayoshi& Oya, Yoshihiro& Ikeda, Kei& Saito, Yasushi…[et al.]. A Functional Polymorphism in B and T Lymphocyte Attenuator Is Associated with Susceptibility to Rheumatoid Arthritis. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-461974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461974