Comparative Study of Regulatory T Cell Function of Human CD25+CD4+ T Cells from Thymocytes, Cord Blood, and Adult Peripheral Blood
Joint Authors
Fujimaki, Wakae
Nagatsu, Masayoshi
Ohnuma, Kei
Dang, Nam H.
Kurosawa, Hiromi
Takahashi, Nozomu
Yoshida, Satoko
Morimoto, Chikao
Uchiyama, Takehiko
Source
Clinical and Developmental Immunology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-09-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
CD25+CD4+ regulatory T cells suppress T cell activation and regulate multiple immune reactions in in vitro and in vivo studies.
To define the regulatory function of human CD25+CD4+ T cells at various stages of maturity, we investigated in detail the functional differences of CD25+CD4+ T cells from thymocytes, cord blood (CB), and adult peripheral blood (APB).
CB CD25+CD4+ T cells displayed low-FOXP3 protein expression level and had no suppressive activity.
In contrast, CD25+CD4+ T cells from thymocytes or APB expressed high expression level of FOXP3 protein associated with significant suppressive activity.
Although CB CD25+CD4+ T cells exhibited no suppressive activity, striking suppressive activity was observed following expansion in culture associated with increased FOXP3 expression and a shift from the CD45RA+ to the CD45RA− phenotype.
These functional differences in CD25+CD4+ T cells from Thy, CB, and APB hence suggest a pathway of maturation for Treg in the peripheral immune system.
American Psychological Association (APA)
Fujimaki, Wakae& Takahashi, Nozomu& Ohnuma, Kei& Nagatsu, Masayoshi& Kurosawa, Hiromi& Yoshida, Satoko…[et al.]. 2008. Comparative Study of Regulatory T Cell Function of Human CD25+CD4+ T Cells from Thymocytes, Cord Blood, and Adult Peripheral Blood. Clinical and Developmental Immunology،Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-461991
Modern Language Association (MLA)
Fujimaki, Wakae…[et al.]. Comparative Study of Regulatory T Cell Function of Human CD25+CD4+ T Cells from Thymocytes, Cord Blood, and Adult Peripheral Blood. Clinical and Developmental Immunology No. 2008 (2008), pp.1-12.
https://search.emarefa.net/detail/BIM-461991
American Medical Association (AMA)
Fujimaki, Wakae& Takahashi, Nozomu& Ohnuma, Kei& Nagatsu, Masayoshi& Kurosawa, Hiromi& Yoshida, Satoko…[et al.]. Comparative Study of Regulatory T Cell Function of Human CD25+CD4+ T Cells from Thymocytes, Cord Blood, and Adult Peripheral Blood. Clinical and Developmental Immunology. 2008. Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-461991
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461991