Therapeutic Potential of Andrographolide Isolated from the Leaves of Andrographis paniculata Nees for Treating Lung Adenocarcinomas
Joint Authors
Tsai, Hsin-Chung
Chen, Chuan-Mu
Yang, Shang-Hsun
Chang, Yi-Chun
Chen, Hsiao-Ling
Tung, Yu-Tang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Andrographolide is one of the major diterpene lactones found in Andrographis paniculata Nees and exhibits remarkable inhibitory effects on various cancers.
In this study, the antipulmonary cancer effects of andrographolide were studied in a lung tumor mouse model induced by human vascular endothelial growth factor A165 (hVEGF-A165).
These results demonstrated that andrographolide significantly reduced the expression of hVEGF-A165 compared with a mock group in the Clara cells of the lungs.
In addition, andrographolide also decreased tumor formation by reducing VEGF, EGFR, Cyclin A, and Cyclin B expression on the transcriptional and translational levels.
These results indicated that andrographolide treatment on the overexpression of VEGF can arrest the cell cycle, which induced pulmonary tumors in transgenic mice.
In conclusion, the antiangiogenesis and chemotherapeutic potential of andrographolide may provide a cure for pulmonary tumors in the future.
American Psychological Association (APA)
Tung, Yu-Tang& Chen, Hsiao-Ling& Tsai, Hsin-Chung& Yang, Shang-Hsun& Chang, Yi-Chun& Chen, Chuan-Mu. 2013. Therapeutic Potential of Andrographolide Isolated from the Leaves of Andrographis paniculata Nees for Treating Lung Adenocarcinomas. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-461999
Modern Language Association (MLA)
Tung, Yu-Tang…[et al.]. Therapeutic Potential of Andrographolide Isolated from the Leaves of Andrographis paniculata Nees for Treating Lung Adenocarcinomas. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-461999
American Medical Association (AMA)
Tung, Yu-Tang& Chen, Hsiao-Ling& Tsai, Hsin-Chung& Yang, Shang-Hsun& Chang, Yi-Chun& Chen, Chuan-Mu. Therapeutic Potential of Andrographolide Isolated from the Leaves of Andrographis paniculata Nees for Treating Lung Adenocarcinomas. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-461999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461999