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Quantitative Proteomic (iTRAQ) Analysis of 1st Trimester Maternal Plasma Samples in Pregnancies at Risk for Preeclampsia
Joint Authors
Jenö, Paul
Hahn, Sinuhe
Kolla, Varaprasad
Moes, Suzette
Lapaire, Olav
Hoesli, Irene
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A current major obstacle is that no reliable screening markers exist to detect pregnancies at risk for preeclampsia.
Quantitative proteomic analysis employing isobaric labelling (iTRAQ) has been suggested to be suitable for the detection of potential plasma biomarkers, a feature we recently verified in analysis of pregnancies with Down syndrome foetuses.
We have now examined whether this approach could yield biomarkers to screen pregnancies at risk for preeclampsia.
In our study, we used maternal plasma samples obtained at 12 weeks of gestation, six from women who subsequently developed preeclampsia and six with uncomplicated deliveries.
In our analysis, we observed elevations in 10 proteins out of 64 proteins in the preeclampsia study group when compared to the healthy control group.
These proteins included clusterin, fibrinogen, fibronectin, and angiotensinogen, increased levels of which are known to be associated with preeclampsia.
An elevation in the immune-modulatory molecule, galectin 3 binding protein, was also noted.
Our pilot study, therefore, indicates that quantitative proteomic iTRAQ analysis could be a useful tool for the detection of new preeclampsia screening markers.
American Psychological Association (APA)
Kolla, Varaprasad& Jenö, Paul& Moes, Suzette& Lapaire, Olav& Hoesli, Irene& Hahn, Sinuhe. 2012. Quantitative Proteomic (iTRAQ) Analysis of 1st Trimester Maternal Plasma Samples in Pregnancies at Risk for Preeclampsia. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-462011
Modern Language Association (MLA)
Kolla, Varaprasad…[et al.]. Quantitative Proteomic (iTRAQ) Analysis of 1st Trimester Maternal Plasma Samples in Pregnancies at Risk for Preeclampsia. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-462011
American Medical Association (AMA)
Kolla, Varaprasad& Jenö, Paul& Moes, Suzette& Lapaire, Olav& Hoesli, Irene& Hahn, Sinuhe. Quantitative Proteomic (iTRAQ) Analysis of 1st Trimester Maternal Plasma Samples in Pregnancies at Risk for Preeclampsia. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-462011
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462011