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The Effects of L-Arginine on Liver Damage in Experimental Acute Cholestasis an Immunohistochemical Study
Joint Authors
Ozsoy, Mustafa
Özyurt, Beyhan
Namlı, Kemal
Var, Ahmet
Ozsoy, Yucel
Coskun, Teoman
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Obstructive jaundice damages critical functions in the liver.
Nitric oxide modulation would influence liver damage induced by biliary obstruction, and little is known about it Acute cholestasis was induced by bile duct ligation (BDL) in two groups of male Sprague-Dawley rats.
L-Arginine or serum physiologic was administered to treatment and control group.
Histopathological and immunohistochemical iNOS expression was investigated in hepatic tissue.
Plasma enzyme activities were increased in acute cholestasis, and that L-arginine treatment partially but significantly prevented the elevation of these markers of liver damage (P< .05).
Also histopathology scoring showed that the liver injury was prevented and immunohistochemical iNOS activity was increased significantly in L-arginine group (P< .05).
This study shows that, after 7 days of biliary obstruction, liver damage is well established and exogenous L-arginine treatment partially but significantly prevented the liver injury in acute cholestasis.
American Psychological Association (APA)
Ozsoy, Yucel& Ozsoy, Mustafa& Coskun, Teoman& Namlı, Kemal& Var, Ahmet& Özyurt, Beyhan. 2011. The Effects of L-Arginine on Liver Damage in Experimental Acute Cholestasis an Immunohistochemical Study. HPB Surgery،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-462016
Modern Language Association (MLA)
Ozsoy, Yucel…[et al.]. The Effects of L-Arginine on Liver Damage in Experimental Acute Cholestasis an Immunohistochemical Study. HPB Surgery No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-462016
American Medical Association (AMA)
Ozsoy, Yucel& Ozsoy, Mustafa& Coskun, Teoman& Namlı, Kemal& Var, Ahmet& Özyurt, Beyhan. The Effects of L-Arginine on Liver Damage in Experimental Acute Cholestasis an Immunohistochemical Study. HPB Surgery. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-462016
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462016