Preventive and Therapeutic Effects of MG132 by Activating Nrf2-ARE Signaling Pathway on Oxidative Stress-Induced Cardiovascular and Renal Injury
Joint Authors
Cai, Lu
Bai, Yang
Cui, Wenpeng
Luo, Ping
Miao, Li-ning
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
So far, cardiovascular and renal diseases have brought us not only huge economic burden but also serious society problems.
Since effective therapeutic strategies are still limited, to find new methods for the prevention or therapy of these diseases is important.
Oxidative stress has been found to play a critical role in the initiation and progression of cardiovascular and renal diseases.
In addition, activation of nuclear-factor-E2-related-factor-2- (Nrf2-) antioxidant-responsive element (ARE) signaling pathway protects cells and tissues from oxidative damage.
As a proteasomal inhibitor, MG132 was reported to activate Nrf2 expression and function, which was accompanied with significant preventive and/or therapeutic effect on cardiovascular and renal diseases under most conditions; therefore, MG132 seems to be a potentially effective drug to be used in the prevention of oxidative damage.
In this paper, we will summarize the information available regarding the effect of MG132 on oxidative stress-induced cardiovascular and renal damage, especially through Nrf2-ARE signaling pathway.
American Psychological Association (APA)
Cui, Wenpeng& Bai, Yang& Luo, Ping& Miao, Li-ning& Cai, Lu. 2013. Preventive and Therapeutic Effects of MG132 by Activating Nrf2-ARE Signaling Pathway on Oxidative Stress-Induced Cardiovascular and Renal Injury. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-462018
Modern Language Association (MLA)
Cui, Wenpeng…[et al.]. Preventive and Therapeutic Effects of MG132 by Activating Nrf2-ARE Signaling Pathway on Oxidative Stress-Induced Cardiovascular and Renal Injury. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-462018
American Medical Association (AMA)
Cui, Wenpeng& Bai, Yang& Luo, Ping& Miao, Li-ning& Cai, Lu. Preventive and Therapeutic Effects of MG132 by Activating Nrf2-ARE Signaling Pathway on Oxidative Stress-Induced Cardiovascular and Renal Injury. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-462018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462018