Acromegaly : Role of Surgery in the Therapeutic Armamentarium
Joint Authors
Aréchiga, Norma
Zepeda, Erick
Guinto, Gerardo
Mercado, Moisés
Abdo, Miguel
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Acromegaly is a complex disease that requires the intervention of a multidisciplinary team.
The most frequent clinical manifestations are growing of distal parts of the body and some areas of the face.
Patients may also present arterial hypertension, diabetes mellitus, colonic polyps, cardiomegaly, neurological and endocrine changes secondary to the presence of a GH-secreting tumor in pituitary or extrapituitary origin, or eutopic hypothalamic GHRH hypersecretion and peripheral GHRH hypersecretion.
Surgery is the first treatment used for most patients, regardless of the cause.
In the great majority of cases, pituitary tumor can be removed through a transsphenoidal approach.
Craniotomy is reserved for those cases with giant tumors, particularly when they grow toward the middle or posterior cranial fossa.
Best surgical results are obtained when the tumor is confined into the sella turcica or if it has a regular suprasellar extension.
When the disease cannot be controlled with surgery, medical treatment is indicated.
Somatostatin analogues are included as the first line of medication, followed by dopamine agonist and growth hormone receptors antagonists.
Radiation therapy can be also indicated in two main forms for residual tumor with medically refractory patients: radiosurgery for small tumors or fractionated stereotactic radiotherapy for larger ones.
American Psychological Association (APA)
Guinto, Gerardo& Abdo, Miguel& Zepeda, Erick& Aréchiga, Norma& Mercado, Moisés. 2012. Acromegaly : Role of Surgery in the Therapeutic Armamentarium. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-462020
Modern Language Association (MLA)
Guinto, Gerardo…[et al.]. Acromegaly : Role of Surgery in the Therapeutic Armamentarium. International Journal of Endocrinology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-462020
American Medical Association (AMA)
Guinto, Gerardo& Abdo, Miguel& Zepeda, Erick& Aréchiga, Norma& Mercado, Moisés. Acromegaly : Role of Surgery in the Therapeutic Armamentarium. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-462020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462020