The Effects of Extended Release Niacin in Combination with Omega 3 Fatty Acid Supplements in the Treatment of Elevated Lipoprotein (a)
Joint Authors
Shry, Eric A.
Slim, Ahmad M.
Helmbold, Alan F.
Castillo-Rojas, Laudino M.
Morgan, Jennifer
Slim, Jennifer N.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-24
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Objective.
To assess the effectiveness of niacin/fish oil combination therapy in reducing Lipoprotein (a) [Lp(a)] levels after twelve weeks of therapy.
Background.
Lipoprotein (a) accumulates in atherosclerotic lesions and promotes smooth muscle cell growth and is both atherogenic and thrombogenic.
A clinical trials of combination therapy for the reduction of Lp(a) has not been previously reported.
Methods.
The study was an observational study following subjects with an elevated Lp(a) (>70 nmol/L) to assess impact of 12 weeks of combination Omega 3FA, niacin, and the Mediterranean diet on Lp(a).
Results.
Twenty three patients were enrolled with 7 patients lost to follow up and 2 patients stopped due to adverse events.
The average Lp(a) reduction in the remaining 14 subjects after 12 weeks of combination therapy was 23% ± 17% [P=.003] with a significant association of the reduction of Lp(a) with increasing baseline levels of Lp(a) [R2=0.633, P=.001].
Conclusions.
There was a significant reduction in Lp(a) levels with combination therapy.
A more pronounced effect was noted in patients with higher baseline levels of Lp(a).
American Psychological Association (APA)
Helmbold, Alan F.& Slim, Jennifer N.& Morgan, Jennifer& Castillo-Rojas, Laudino M.& Shry, Eric A.& Slim, Ahmad M.. 2010. The Effects of Extended Release Niacin in Combination with Omega 3 Fatty Acid Supplements in the Treatment of Elevated Lipoprotein (a). Cholesterol،Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-462027
Modern Language Association (MLA)
Helmbold, Alan F.…[et al.]. The Effects of Extended Release Niacin in Combination with Omega 3 Fatty Acid Supplements in the Treatment of Elevated Lipoprotein (a). Cholesterol No. 2010 (2010), pp.1-3.
https://search.emarefa.net/detail/BIM-462027
American Medical Association (AMA)
Helmbold, Alan F.& Slim, Jennifer N.& Morgan, Jennifer& Castillo-Rojas, Laudino M.& Shry, Eric A.& Slim, Ahmad M.. The Effects of Extended Release Niacin in Combination with Omega 3 Fatty Acid Supplements in the Treatment of Elevated Lipoprotein (a). Cholesterol. 2010. Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-462027
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462027