Thyroid Functions and Bipolar Affective Disorder

Author

Chakrabarti, Subho

Source

Journal of Thyroid Research

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-07-26

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Biology
Diseases
Medicine

Abstract EN

Accumulating evidence suggests that hypothalamo-pituitary-thyroid (HPT) axis dysfunction is relevant to the pathophysiology and clinical course of bipolar affective disorder.

Hypothyroidism, either overt or more commonly subclinical, appears to the commonest abnormality found in bipolar disorder.

The prevalence of thyroid dysfunction is also likely to be greater among patients with rapid cycling and other refractory forms of the disorder.

Lithium-treatment has potent antithyroid effects and can induce hypothyroidism or exacerbate a preexisting hypothyroid state.

Even minor perturbations of the HPT axis may affect the outcome of bipolar disorder, necessitating careful monitoring of thyroid functions of patients on treatment.

Supplementation with high dose thyroxine can be considered in some patients with treatment-refractory bipolar disorder.

Neurotransmitter, neuroimaging, and genetic studies have begun to provide clues, which could lead to an improved understanding of the thyroid-bipolar disorder connection, and more optimal ways of managing this potentially disabling condition.

American Psychological Association (APA)

Chakrabarti, Subho. 2011. Thyroid Functions and Bipolar Affective Disorder. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-462042

Modern Language Association (MLA)

Chakrabarti, Subho. Thyroid Functions and Bipolar Affective Disorder. Journal of Thyroid Research No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-462042

American Medical Association (AMA)

Chakrabarti, Subho. Thyroid Functions and Bipolar Affective Disorder. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-462042

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-462042