Carbon Monoxide Protects against Hepatic IschemiaReperfusion Injury via ROS-Dependent Akt Signaling and Inhibition of Glycogen Synthase Kinase 3β
Joint Authors
Jeong, Sun-oh
Ryter, Stefan W.
Kim, Hyo Jeong
Cho, Gyeong Jae
Joe, Yeonsoo
Kong, Jin Sun
Chung, Hun Taeg
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Carbon monoxide (CO) may exert important roles in physiological and pathophysiological states through the regulation of cellular signaling pathways.
CO can protect organ tissues from ischemia/reperfusion (I/R) injury by modulating intracellular redox status and by inhibiting inflammatory, apoptotic, and proliferative responses.
However, the cellular mechanisms underlying the protective effects of CO in organ I/R injury remain incompletely understood.
In this study, a murine model of hepatic warm I/R injury was employed to assess the role of glycogen synthase kinase-3 (GSK3) and phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathways in the protective effects of CO against inflammation and injury.
Inhibition of GSK3 through the PI3K/Akt pathway played a crucial role in CO-mediated protection.
CO treatment increased the phosphorylation of Akt and GSK3-beta (GSK3β) in the liver after I/R injury.
Furthermore, administration of LY294002, an inhibitor of PI3K, compromised the protective effect of CO and decreased the level of phospho-GSK3β after I/R injury.
These results suggest that CO protects against liver damage by maintaining GSK3β phosphorylation, which may be mediated by the PI3K/Akt signaling pathway.
Our study provides additional support for the therapeutic potential of CO in organ injury and identifies GSK3β as a therapeutic target for CO in the amelioration of hepatic injury.
American Psychological Association (APA)
Kim, Hyo Jeong& Joe, Yeonsoo& Kong, Jin Sun& Jeong, Sun-oh& Cho, Gyeong Jae& Ryter, Stefan W.…[et al.]. 2013. Carbon Monoxide Protects against Hepatic IschemiaReperfusion Injury via ROS-Dependent Akt Signaling and Inhibition of Glycogen Synthase Kinase 3β. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-462049
Modern Language Association (MLA)
Kim, Hyo Jeong…[et al.]. Carbon Monoxide Protects against Hepatic IschemiaReperfusion Injury via ROS-Dependent Akt Signaling and Inhibition of Glycogen Synthase Kinase 3β. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-462049
American Medical Association (AMA)
Kim, Hyo Jeong& Joe, Yeonsoo& Kong, Jin Sun& Jeong, Sun-oh& Cho, Gyeong Jae& Ryter, Stefan W.…[et al.]. Carbon Monoxide Protects against Hepatic IschemiaReperfusion Injury via ROS-Dependent Akt Signaling and Inhibition of Glycogen Synthase Kinase 3β. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-462049
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462049