The Inhibitory Effect of Ellagic Acid on Cell Growth of Ovarian Carcinoma Cells
Joint Authors
Lu, Li-Cheng
Chen, Yu-Jen
Hsu, Chih-Ping
Yao, Shih-Ping
Tsai, Ming-Hsiu
Chen, Yi-Ying
Chung, Yuan-Chiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Ellagic acid (EA) is able to inhibit the growth of several cancer cells; however, its effect on human ovarian carcinoma cells has not yet been investigated.
Ovarian carcinoma ES-2 and PA-1 cells were treated with EA (10~100 μM) and assessed for viability, cell cycle, apoptosis, anoikis, autophagy, and chemosensitivity to doxorubicin and their molecular mechanisms.
EA inhibited cell proliferation in a dose- and time-dependent manner by arresting both cell lines at the G1 phase of the cell cycle, which were from elevating p53 and Cip1/p21 and decreasing cyclin D1 and E levels.
EA also induced caspase-3-mediated apoptosis by increasing the Bax : Bcl-2 ratio and restored anoikis in both cell lines.
The enhancement of apoptosis and/or inhibition of autophagy in these cells by EA assisted the chemotherapy efficacy.
The results indicated that EA is a potential novel chemoprevention and treatment assistant agent for human ovarian carcinoma.
American Psychological Association (APA)
Chung, Yuan-Chiang& Lu, Li-Cheng& Tsai, Ming-Hsiu& Chen, Yu-Jen& Chen, Yi-Ying& Yao, Shih-Ping…[et al.]. 2013. The Inhibitory Effect of Ellagic Acid on Cell Growth of Ovarian Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-462070
Modern Language Association (MLA)
Chung, Yuan-Chiang…[et al.]. The Inhibitory Effect of Ellagic Acid on Cell Growth of Ovarian Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-462070
American Medical Association (AMA)
Chung, Yuan-Chiang& Lu, Li-Cheng& Tsai, Ming-Hsiu& Chen, Yu-Jen& Chen, Yi-Ying& Yao, Shih-Ping…[et al.]. The Inhibitory Effect of Ellagic Acid on Cell Growth of Ovarian Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-462070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462070