Investigation of the Effect of Rice Wine on the Metabolites of the Main Components of Herbal Medicine in Rat Urine by Ultrahigh-Performance Liquid Chromatography-QuadrupoleTime-of-Flight Mass Spectrometry : A Case Study on Cornus officinalis
Joint Authors
Xu, Zhiwei
Cai, Baochang
Cao, Gang
Tu, Sicong
Cai, Hao
Yue, Xianke
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ultrahigh-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (UPLC-QTOF/MS) was developed for rapid and sensitive analysis of the effect of rice wine on the metabolites of the main components of herbal medicine in rat urine.
Using Cornus officinalis as a model of herbal medicine, the metabolite profiles of crude and processed (steaming the crude drug presteeped in rice wine) Cornus officinalis extracts in rat urine were investigated.
The metabolites of Cornus officinalis were identified by using dynamic adjustment of the fragmentor voltage to produce structure-relevant fragment ions.
In this work, we identified the parent compounds and metabolites of crude and processed Cornus officinalis in rats.
In total, three parent compounds and seventeen new metabolites of Cornus officinalis were found in rats.
The contents of the parent compounds and metabolites in vivo varied significantly after intragastric (i.g.) administration of aqueous extracts of crude and processed Cornus officinalis.
Data from this study suggests that UPLC-QTOF/MS could be used as a potential tool for uncovering the effects of excipients found in the metabolites of the main components of herbal medicine, in vivo, to predict and discover the processing mechanisms of herbal medicine.
American Psychological Association (APA)
Cao, Gang& Cai, Hao& Yue, Xianke& Tu, Sicong& Cai, Baochang& Xu, Zhiwei. 2013. Investigation of the Effect of Rice Wine on the Metabolites of the Main Components of Herbal Medicine in Rat Urine by Ultrahigh-Performance Liquid Chromatography-QuadrupoleTime-of-Flight Mass Spectrometry : A Case Study on Cornus officinalis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-462072
Modern Language Association (MLA)
Cao, Gang…[et al.]. Investigation of the Effect of Rice Wine on the Metabolites of the Main Components of Herbal Medicine in Rat Urine by Ultrahigh-Performance Liquid Chromatography-QuadrupoleTime-of-Flight Mass Spectrometry : A Case Study on Cornus officinalis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-462072
American Medical Association (AMA)
Cao, Gang& Cai, Hao& Yue, Xianke& Tu, Sicong& Cai, Baochang& Xu, Zhiwei. Investigation of the Effect of Rice Wine on the Metabolites of the Main Components of Herbal Medicine in Rat Urine by Ultrahigh-Performance Liquid Chromatography-QuadrupoleTime-of-Flight Mass Spectrometry : A Case Study on Cornus officinalis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-462072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462072