Managing the Combination of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome with Chinese Herbal Extracts in High-Fat-Diet Fed Rats
Joint Authors
Xiao, Linda
Wang, Zhenzhong
Lao, Weiguo
Xiao, Wei
Seale, J. Paul
Qu, Xianqin
Kamal, Mohamed A.
Tan, Yi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome (MetS).
The aim of the study was to evaluate the effects of Chinese herbal extracts from Salvia miltiorrhiza and Gardenia jasminoides (SGE) on the combination of NAFLD and MetS induced by a high-fat diet (HFD) in rats.
After 6 weeks of HFD feeding, rats (n=10 each group) were treated with saline, rosiglitazone (RSG), and SGE for 4 weeks.
HFD rats were obese, hyperinsulinemic, hyperlipidemic and increased hepatic enzymes with the histological images of NAFLD.
Treatment with SGE significantly reduced serum triglycerides (TG), nonesterified fatty acids and enhanced insulin sensitivity, and ameliorated the elevated serum hepatic enzymes compared with HFD-saline group.
SGE treatment also attenuated hepatic TG by 18.5% (P<0.05).
Histological stains showed SGE decreased lipids droplets in hepatocytes (P<0.05) and normalized macrovesicular steatosis in HFD rats.
Significant reduction of TNF-α and IL6 in adipose tissue was detected in SGE treated rats.
The anti-inflammatory action may be, at least in part, the mechanism of SGE on MetS associated with NAFLD.
This study discovered that SGE is capable of managing metabolic and histological abnormalities of NAFLD and MetS.
SGE may be an optimal treatment for the combination of NAFLD and MetS.
American Psychological Association (APA)
Tan, Yi& Lao, Weiguo& Xiao, Linda& Wang, Zhenzhong& Xiao, Wei& Kamal, Mohamed A.…[et al.]. 2013. Managing the Combination of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome with Chinese Herbal Extracts in High-Fat-Diet Fed Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-462076
Modern Language Association (MLA)
Tan, Yi…[et al.]. Managing the Combination of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome with Chinese Herbal Extracts in High-Fat-Diet Fed Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-462076
American Medical Association (AMA)
Tan, Yi& Lao, Weiguo& Xiao, Linda& Wang, Zhenzhong& Xiao, Wei& Kamal, Mohamed A.…[et al.]. Managing the Combination of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome with Chinese Herbal Extracts in High-Fat-Diet Fed Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-462076
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462076