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Cellular Liver Regeneration after Extended Hepatic Resection in Pigs
Joint Authors
Schenk, Martin
Ladurner, Ruth
Glatzle, Jörg
Traub, Frank
Königsrainer, Alfred
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The liver has an enormous capacity to regenerate itself.
The aim of this study was to evaluate whether the regeneration is due to hypertrophy or hyperplasia of the remnant liver after extended resection and whether a portosystemic shunt is beneficial.
Material and methods.
An extended left hemihepatectomy was performed in 25 pigs, and in 14 after performing a portosystemic shunt.
During follow up, liver regeneration was estimated by macroscopic markers such as liver volume and size of the portal fields [mm2] as well as the amount of hepatocytes per portal field and the amount of hepatocytes per mm2.
Results.
Regardless of the operation procedure, the volume of the remnant liver increased about 2.5 fold at the end of the first week after resection.
The size of the portal fields increased significantly as well as the number of hepatocytes in the portal fields.
Interestingly, the number of hepatocytes per mm2 remained the same.
Conclusion.
After extended resection, liver regeneration was achieved by an extensive and significant hyperplasia of hepatocytes within the preexisting portal fields and not by de novo synthesis of new portal fields.
However, there was no difference in liver regeneration regarding the operation procedure performed with or without portosystemic shunt.
American Psychological Association (APA)
Ladurner, Ruth& Traub, Frank& Schenk, Martin& Königsrainer, Alfred& Glatzle, Jörg. 2009. Cellular Liver Regeneration after Extended Hepatic Resection in Pigs. HPB Surgery،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-462077
Modern Language Association (MLA)
Ladurner, Ruth…[et al.]. Cellular Liver Regeneration after Extended Hepatic Resection in Pigs. HPB Surgery No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-462077
American Medical Association (AMA)
Ladurner, Ruth& Traub, Frank& Schenk, Martin& Königsrainer, Alfred& Glatzle, Jörg. Cellular Liver Regeneration after Extended Hepatic Resection in Pigs. HPB Surgery. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-462077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462077