Analysis of the Thymidylate Synthase Gene Structure in Colorectal Cancer Patients and Its Possible Relation with the 5-Fluorouracil Drug Response
Joint Authors
Feo, S.
Cajozzo, M.
Gulotta, G.
Sanguedolce, R.
Sanguedolce, G.
Antona, A.
Calascibetta, A.
Contino, Flavia
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and it is the target for the 5-Fluorouracil (5-FU) activity.
Barbour et al.
showed that variant structural forms of TS in tumour cell lines confer resistance to fluoropyrimidines.
We planned to perform the whole TS gene structure by means of sequencing techniques in human colorectal cancer (CRC) samples to try to identify the presence of any possible TS variant form that could be responsible of fluoropyrimidines drug resistance and of the worse prognosis.
We performed the TS-DNA gene sequence in 68 CRC from patients of A, B, and C Dukes' stages and different histological grade, but we did not find any mutation in the TS-DNA structure.
In the future we intend to widen the TS structure analysis to the metastatic CRCs, because due to their higher genomic instability, they could present a TS variant form responsible of the fluoropyrimidines drug resistance and the worse prognosis.
American Psychological Association (APA)
Calascibetta, A.& Contino, Flavia& Feo, S.& Gulotta, G.& Cajozzo, M.& Antona, A.…[et al.]. 2010. Analysis of the Thymidylate Synthase Gene Structure in Colorectal Cancer Patients and Its Possible Relation with the 5-Fluorouracil Drug Response. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-462080
Modern Language Association (MLA)
Calascibetta, A.…[et al.]. Analysis of the Thymidylate Synthase Gene Structure in Colorectal Cancer Patients and Its Possible Relation with the 5-Fluorouracil Drug Response. Journal of Nucleic Acids No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-462080
American Medical Association (AMA)
Calascibetta, A.& Contino, Flavia& Feo, S.& Gulotta, G.& Cajozzo, M.& Antona, A.…[et al.]. Analysis of the Thymidylate Synthase Gene Structure in Colorectal Cancer Patients and Its Possible Relation with the 5-Fluorouracil Drug Response. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-462080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462080