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Analysis of Candidate Genes in Occurrence and Growth of Colorectal Adenomas
Joint Authors
Nalet, Bernard
Bonaiti-Pellié, Catherine
Laurent-Puig, Pierre
Pariente, Alexandre
Olschwang, Sylviane
Vernerey, Déwi
Lafon, Jacques
Bonithon-Kopp, Claire
Cottet, Vanessa
Faivre, Jean
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Predisposition to sporadic colorectal tumours is influenced by genes with minor phenotypic effects.
A case-control study was set up on 295 patients treated for a large adenoma matched with polyp-free individuals on gender, age, and geographic origin in a 1 : 2 proportion.
A second group of 302 patients treated for a small adenoma was also characterized to distinguish effects on adenoma occurrence and growth.
We focussed the study on 38 single nucleotide polymorphisms (SNPs) encompassing 14 genes involved in colorectal carcinogenesis.
Effect of SNPs was tested using unconditional logistic regression.
Comparisons were made for haplotypes within a given gene and for biologically relevant genes combinations using the combination test.
The APC p.Glu1317Gly variant appeared to influence the adenoma growth (P=.04, exact test) but not its occurrence.
This result needs to be replicated and genome-wide association studies may be necessary to fully identify low-penetrance alleles involved in early stages of colorectal tumorigenesis.
American Psychological Association (APA)
Olschwang, Sylviane& Vernerey, Déwi& Cottet, Vanessa& Pariente, Alexandre& Nalet, Bernard& Lafon, Jacques…[et al.]. 2009. Analysis of Candidate Genes in Occurrence and Growth of Colorectal Adenomas. Journal of Oncology،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-462084
Modern Language Association (MLA)
Olschwang, Sylviane…[et al.]. Analysis of Candidate Genes in Occurrence and Growth of Colorectal Adenomas. Journal of Oncology No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-462084
American Medical Association (AMA)
Olschwang, Sylviane& Vernerey, Déwi& Cottet, Vanessa& Pariente, Alexandre& Nalet, Bernard& Lafon, Jacques…[et al.]. Analysis of Candidate Genes in Occurrence and Growth of Colorectal Adenomas. Journal of Oncology. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-462084
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462084