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Endometriosis, Angiogenesis and Tissue Factor
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
Tissue factor (TF), is a cellular receptor that binds the factor VII/VIIa to initiate the blood coagulation cascade.
In addition to its role as the initiator of the hemostatic cascade, TF is known to be involved in angiogenesis via intracellular signaling that utilizes the protease activated receptor-2 (PAR-2).
We now review the physiologic expression of TF in the endometrium and its altered expression in multiple cell types derived from eutopic and ectopic endometrium from women with endometriosis compared with normal endometrium.
Our findings suggest that TF might be an ideal target for therapeutic intervention in endometriosis.
We have employed a novel immunoconjugate molecule known as Icon and were able to eradicate endometrial lesions in a mouse model of endometriosis without affecting fertility.
These findings have major implications for potential treatment in humans.
American Psychological Association (APA)
Krikun, Graciela. 2012. Endometriosis, Angiogenesis and Tissue Factor. Scientifica،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-462088
Modern Language Association (MLA)
Krikun, Graciela. Endometriosis, Angiogenesis and Tissue Factor. Scientifica No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-462088
American Medical Association (AMA)
Krikun, Graciela. Endometriosis, Angiogenesis and Tissue Factor. Scientifica. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-462088
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462088