New Sensitive Kinetic Spectrophotometric Methods for Determination of Omeprazole in Dosage Forms
Author
Source
International Journal of Analytical Chemistry
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
New rapid, sensitive, and accurate kinetic spectrophotometric methods were developed, for the first time, to determine omeprazole (OMZ) in its dosage forms.
The methods were based on the formation of charge-transfer complexes with both iodine and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ).
The variables that affected the reactions were carefully studied and optimized.
The formed complexes and the site of interaction were examined by UV/VIS, IR, and 1H-NMR techniques, and computational molecular modeling.
Under optimum conditions, the stoichiometry of the reactions between OMZ and the acceptors was found to be 1 : 1.
The order of the reactions and the specific rate constants were determined.
The thermodynamics of the complexes were computed and the mechanism of the reactions was postulated.
The initial rate and fixed time methods were utilized for the determination of OMZ concentrations.
The linear ranges for the proposed methods were 0.10–3.00 and 0.50–25.00 μg mL-1 with the lowest LOD of 0.03 and 0.14 μg mL-1 for iodine and DDQ, respectively.
Analytical performance of the methods was statistically validated; RSD was <1.25% for the precision and <1.95% for the accuracy.
The proposed methods were successfully applied to the analysis of OMZ in its dosage forms; the recovery was 98.91–100.32% ± 0.94–1.84, and was found to be comparable with that of reference method.
American Psychological Association (APA)
Mahmoud, Ashraf M.. 2009. New Sensitive Kinetic Spectrophotometric Methods for Determination of Omeprazole in Dosage Forms. International Journal of Analytical Chemistry،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-462113
Modern Language Association (MLA)
Mahmoud, Ashraf M.. New Sensitive Kinetic Spectrophotometric Methods for Determination of Omeprazole in Dosage Forms. International Journal of Analytical Chemistry No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-462113
American Medical Association (AMA)
Mahmoud, Ashraf M.. New Sensitive Kinetic Spectrophotometric Methods for Determination of Omeprazole in Dosage Forms. International Journal of Analytical Chemistry. 2009. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-462113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462113