Combination Therapies for the Treatment of Advanced Melanoma : A Review of Current Evidence
Joint Authors
Arkenau, Hendrik-Tobias
Voskoboynik, Mark
Source
Biochemistry Research International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The treatment of advanced melanoma has been revolutionised in recent years with the advent of a range of new therapies.
BRAF inhibitors, such as vemurafenib, have demonstrated improvements in the overall survival of patients with advanced melanoma that harbour a BRAF V600 mutation.
Alongside these targeted therapies, novel immune-checkpoint inhibitors, such as ipilimumab, have also been developed and have produced similarly improved outcomes for patients.
For the first time in the history of melanoma, monotherapy with each of these drugs has produced improvements in the overall survival of patients with advanced disease.
Building on this initial success, there has been intense interest in developing combination therapies predominantly with either dual blockade of the MAPK oncogenic pathway or dual immune-checkpoint blockade.
The current evidence for the use of these combination therapies will be presented here.
American Psychological Association (APA)
Voskoboynik, Mark& Arkenau, Hendrik-Tobias. 2014. Combination Therapies for the Treatment of Advanced Melanoma : A Review of Current Evidence. Biochemistry Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-462114
Modern Language Association (MLA)
Voskoboynik, Mark& Arkenau, Hendrik-Tobias. Combination Therapies for the Treatment of Advanced Melanoma : A Review of Current Evidence. Biochemistry Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-462114
American Medical Association (AMA)
Voskoboynik, Mark& Arkenau, Hendrik-Tobias. Combination Therapies for the Treatment of Advanced Melanoma : A Review of Current Evidence. Biochemistry Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-462114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462114