Menadione : Sodium Orthovanadate Combination Eliminates and Inhibits Migration of Detached Cancer Cells
Joint Authors
Yakisich, Juan Sebastian
Siden, Åke
Delwar, Zahid M.
Cruz, Mabel H.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Exposure of cancer cells to anticancer agents in cultures induces detachment of cells that are usually considered dead.
These drug-induced detached cells (D-IDCs) may represent a clinical problem for chemotherapy since they may survive anoikis, enter the circulation, invade other tissues and resume proliferation, creating a metastasis, especially in tissues where the bioavailability of anticancer agents is not enough to eliminate all cancer cells.
In this study we evaluated the antiproliferative effect of menadione : sodium orthovanadate (M : SO) combination on A549 lung cancer cells as well as the ability of M : SO to induce cell detachment.
In addition, we followed the fate and chemosensitivity of M : SO-induced detached cells.
Using transwell chambers, we found that a fraction of the M : SO-induced detached cells were viable and, furthermore, were able to migrate, re-attach, and resume proliferation when re-incubated in drug-free media.
The total elimination of A549 detachment-resistant cells and M : SO-induced detached cells were successfully eliminated by equivalent M : SO concentration (17.5 μM : 17.5 μM).
Thus, M : SO prevented cell migration.
Similar results were obtained on DBTRG.05MG human glioma cells.
Our data guarantee further studies to evaluate the in vivo occurrence of D-IDCs, their implications for invasiveness and metastasis and their sensitivity to anticancer drugs.
American Psychological Association (APA)
Delwar, Zahid M.& Siden, Åke& Cruz, Mabel H.& Yakisich, Juan Sebastian. 2012. Menadione : Sodium Orthovanadate Combination Eliminates and Inhibits Migration of Detached Cancer Cells. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-462118
Modern Language Association (MLA)
Delwar, Zahid M.…[et al.]. Menadione : Sodium Orthovanadate Combination Eliminates and Inhibits Migration of Detached Cancer Cells. ISRN Pharmacology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-462118
American Medical Association (AMA)
Delwar, Zahid M.& Siden, Åke& Cruz, Mabel H.& Yakisich, Juan Sebastian. Menadione : Sodium Orthovanadate Combination Eliminates and Inhibits Migration of Detached Cancer Cells. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-462118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462118