Developing a Deeper Understanding of Autism : Connecting Knowledge through Literature Mining
Joint Authors
Cestnik, Bojan
Urbančič, Tanja
Petrič, Ingrid
Macedoni-Lukšič, Marta
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In the field of autism, an enormous increase in available information makes it very difficult to connect fragments of knowledge into a more coherent picture.
We present a literature mining method, RaJoLink, to search for matched themes in unrelated literature that may contribute to a better understanding of complex pathological conditions, such as autism.
214 full text articles on autism, published in PubMed, served as a source of data.
Using ontology construction, we identified the main concepts of what is already known about autism.
Then, the RaJoLink method, based on Swanson's ABC model, was used to reveal potentially interesting, but not yet investigated, connections between different concepts in research.
Among the more interesting concepts identified with RaJoLink in our study were calcineurin and NF-kappaB.
Both terms can be linked to neuro-immune abnormalities in the brain of patients with autism.
Further research is needed to provide stronger evidence about calcineurin and NF-kappaB involvement in autism.
However, the analysis presented confirms that this method could support experts on their way towards discovering hidden relationships and towards a better understanding of the disorder.
American Psychological Association (APA)
Macedoni-Lukšič, Marta& Petrič, Ingrid& Cestnik, Bojan& Urbančič, Tanja. 2011. Developing a Deeper Understanding of Autism : Connecting Knowledge through Literature Mining. Autism Research and Treatment،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-462126
Modern Language Association (MLA)
Macedoni-Lukšič, Marta…[et al.]. Developing a Deeper Understanding of Autism : Connecting Knowledge through Literature Mining. Autism Research and Treatment No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-462126
American Medical Association (AMA)
Macedoni-Lukšič, Marta& Petrič, Ingrid& Cestnik, Bojan& Urbančič, Tanja. Developing a Deeper Understanding of Autism : Connecting Knowledge through Literature Mining. Autism Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-462126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462126