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Autologous Bone Marrow Stem Cells in the Treatment of Chronic Liver Disease
Joint Authors
Spalding, Duncan
Xi, Feng
Pai, Madhava
Habib, Nagy A.
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Chronic liver disease (CLD) is increasing worldwide yet there has been no major advance in effective therapies for almost five decades.
There is mounting evidence that adult haematopoietic stem cells (HSC) are capable of differentiating into many types of tissue, including skeletal and cardiac muscle, neuronal cells, pneumocytes and hepatocytes.
These recent advances in regenerative medicine have brought hope for patients with liver cirrhosis awaiting transplantation.
New findings in adult stem cell biology are transforming our understanding of tissue repair raising hopes of successful regenerative hepatology.
Although all clinical trials to date have shown some improvement in liver function and CD34+ cells have been used safely for BM transplantation for over 20 years, only randomised controlled clinical trials will be able to fully assess the potential clinical benefit of adult stem cell therapy for patients with CLD.
This article focuses on the potential of bone marrow stem cells (BMSCs) in the management of CLD and the unresolved issues regarding their role.
We also outline the different mechanisms by which stem cells may impact on liver disease.
American Psychological Association (APA)
Pai, Madhava& Spalding, Duncan& Xi, Feng& Habib, Nagy A.. 2011. Autologous Bone Marrow Stem Cells in the Treatment of Chronic Liver Disease. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-462128
Modern Language Association (MLA)
Pai, Madhava…[et al.]. Autologous Bone Marrow Stem Cells in the Treatment of Chronic Liver Disease. International Journal of Hepatology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-462128
American Medical Association (AMA)
Pai, Madhava& Spalding, Duncan& Xi, Feng& Habib, Nagy A.. Autologous Bone Marrow Stem Cells in the Treatment of Chronic Liver Disease. International Journal of Hepatology. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-462128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462128