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Angiotensin-Converting Enzyme 2 : The First Decade
Joint Authors
Clarke, Nicola E.
Turner, Anthony J.
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The renin-angiotensin system (RAS) is a critical regulator of hypertension, primarily through the actions of the vasoactive peptide Ang II, which is generated by the action of angiotensin-converting enzyme (ACE) mediating an increase in blood pressure.
The discovery of ACE2, which primarily metabolises Ang II into the vasodilatory Ang-(1-7), has added a new dimension to the traditional RAS.
As a result there has been huge interest in ACE2 over the past decade as a potential therapeutic for lowering blood pressure, especially elevation resulting from excess Ang II.
Studies focusing on ACE2 have helped to reveal other actions of Ang-(1-7), outside vasodilation, such as antifibrotic and antiproliferative effects.
Moreover, investigations focusing on ACE2 have revealed a variety of roles not just catalytic but also as a viral receptor and amino acid transporter.
This paper focuses on what is known about ACE2 and its biological roles, paying particular attention to the regulation of ACE2 expression.
In light of the entrance of human recombinant ACE2 into clinical trials, we discuss the potential use of ACE2 as a therapeutic and highlight some pertinent questions that still remain unanswered about ACE2.
American Psychological Association (APA)
Clarke, Nicola E.& Turner, Anthony J.. 2011. Angiotensin-Converting Enzyme 2 : The First Decade. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-462147
Modern Language Association (MLA)
Clarke, Nicola E.& Turner, Anthony J.. Angiotensin-Converting Enzyme 2 : The First Decade. International Journal of Hypertension No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-462147
American Medical Association (AMA)
Clarke, Nicola E.& Turner, Anthony J.. Angiotensin-Converting Enzyme 2 : The First Decade. International Journal of Hypertension. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-462147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462147