![](/images/graphics-bg.png)
Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of RuralUrban Environment as a Possible Effect Modifier
Joint Authors
Janipalli, C. S.
Evans, D. M.
Chandak, G. R.
Sullivan, R. M.
Timpson, N. J.
Taylor, A. E.
Dudbridge, F.
Sandeep, M. N.
Kranthi Kumar, M. V.
Bowen, L.
Prabhakaran, D.
Kinra, Sanjay
Vinay, D. G.
Ben-Shlomo, Y.
Smitha, P.
Aruna, M.
Ebrahim, S.
Reddy, K. S.
Davey Smith, G.
Gupta, V.
Giambartolomei, C.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Few studies have investigated the association between genetic variation and obesity traits in Indian populations or the role of environmental factors as modifiers of these relationships.
In the context of rapid urbanisation, resulting in significant lifestyle changes, understanding the aetiology of obesity is important.
We investigated associations of FTO and MC4R variants with obesity traits in 3390 sibling pairs from four Indian cities, most of whom were discordant for current dwelling (rural or urban).
The FTO variant rs9939609 predicted increased weight (0.09 Z-scores, 95% CI: 0.03, 0.15) and BMI (0.08 Z-scores, 95% CI: 0.02, 0.14).
The MC4R variant rs17782313 was weakly associated with weight and hip circumference (P<.05).
There was some indication that the association between FTO and weight was stronger in urban than that in rural dwellers (P for interaction = .03), but no evidence for effect modification by diet or physical activity.
Further studies are needed to investigate ways in which urban environment may modify genetic risk of obesity.
American Psychological Association (APA)
Taylor, A. E.& Sandeep, M. N.& Janipalli, C. S.& Giambartolomei, C.& Evans, D. M.& Kranthi Kumar, M. V.…[et al.]. 2011. Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of RuralUrban Environment as a Possible Effect Modifier. Journal of Obesity،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-462167
Modern Language Association (MLA)
Taylor, A. E.…[et al.]. Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of RuralUrban Environment as a Possible Effect Modifier. Journal of Obesity No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-462167
American Medical Association (AMA)
Taylor, A. E.& Sandeep, M. N.& Janipalli, C. S.& Giambartolomei, C.& Evans, D. M.& Kranthi Kumar, M. V.…[et al.]. Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of RuralUrban Environment as a Possible Effect Modifier. Journal of Obesity. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-462167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462167