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A Chinese Herbal Decoction, Danggui Buxue Tang, Stimulates Proliferation, Differentiation and Gene Expression of Cultured Osteosarcoma Cells : Genomic Approach to Reveal Specific Gene Activation
Joint Authors
Cheung, Jerry K. H.
Zhao, Kui J.
Li, Jun
Choi, Roy C. Y.
Lau, Faye T. C.
Cheung, Anna W. H.
Duan, Ran
Chu, Glanice K. Y.
Tsim, Karl Wah-Keung
Li, Winnie Z. M.
Gao, Qiu T.
Dong, Tina T. X.
Ding, An W.
Zhu, Judy T. T.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Danggui Buxue Tang (DBT), a Chinese herbal decoction used to treat ailments in women, contains Radix Astragali (Huangqi; RA) and Radix Angelicae Sinensis (Danggui; RAS).
When DBT was applied onto cultured MG-63 cells, an increase of cell proliferation and differentiation of MG-63 cell were revealed: both of these effects were significantly higher in DBT than RA or RAS extract.
To search for the biological markers that are specifically regulated by DBT, DNA microarray was used to reveal the gene expression profiling of DBT in MG-63 cells as compared to that of RA- or RAS-treated cells.
Amongst 883 DBT-regulated genes, 403 of them are specifically regulated by DBT treatment, including CCL-2, CCL-7, CCL-8, and galectin-9.
The signaling cascade of this DBT-regulated gene expression was also elucidated in cultured MG-63 cells.
The current results reveal the potential usage of this herbal decoction in treating osteoporosis and suggest the uniqueness of Chinese herbal decoction that requires a well-defined formulation.
The DBT-regulated genes in the culture could serve as biological responsive markers for quality assurance of the herbal preparation.
American Psychological Association (APA)
Choi, Roy C. Y.& Gao, Qiu T.& Cheung, Anna W. H.& Zhu, Judy T. T.& Lau, Faye T. C.& Li, Jun…[et al.]. 2011. A Chinese Herbal Decoction, Danggui Buxue Tang, Stimulates Proliferation, Differentiation and Gene Expression of Cultured Osteosarcoma Cells : Genomic Approach to Reveal Specific Gene Activation. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-462169
Modern Language Association (MLA)
Choi, Roy C. Y.…[et al.]. A Chinese Herbal Decoction, Danggui Buxue Tang, Stimulates Proliferation, Differentiation and Gene Expression of Cultured Osteosarcoma Cells : Genomic Approach to Reveal Specific Gene Activation. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-462169
American Medical Association (AMA)
Choi, Roy C. Y.& Gao, Qiu T.& Cheung, Anna W. H.& Zhu, Judy T. T.& Lau, Faye T. C.& Li, Jun…[et al.]. A Chinese Herbal Decoction, Danggui Buxue Tang, Stimulates Proliferation, Differentiation and Gene Expression of Cultured Osteosarcoma Cells : Genomic Approach to Reveal Specific Gene Activation. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-462169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462169