Niobium Uptake and Release by Bacterial Ferric Ion Binding Protein
Joint Authors
Campopiano, Dominic
Shi, Yanbo
Harvey, Ian
Sadler, Peter J.
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ferric ion binding proteins (Fbps) transport FeIII across the periplasm and are vital for the virulence of many Gram negative bacteria.
Iron(III) is tightly bound in a hinged binding cleft with octahedral coordination geometry involving binding to protein side chains (including tyrosinate residues) together with a synergistic anion such as phosphate.
Niobium compounds are of interest for their potential biological activity, which has been little explored.
We have studied the binding of cyclopentadienyl and nitrilotriacetato NbV complexes to the Fbp from Neisseria gonorrhoeae by UV-vis spectroscopy, chromatography, ICP-OES, mass spectrometry, and Nb K-edge X-ray absorption spectroscopy.
These data suggest that NbV binds strongly to Fbp and that a dinuclear NbV centre can be readily accommodated in the interdomain binding cleft.
The possibility of designing niobium-based antibiotics which block iron uptake by pathogenic bacteria is discussed.
American Psychological Association (APA)
Shi, Yanbo& Harvey, Ian& Campopiano, Dominic& Sadler, Peter J.. 2010. Niobium Uptake and Release by Bacterial Ferric Ion Binding Protein. Bioinorganic Chemistry and Applications،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-462172
Modern Language Association (MLA)
Shi, Yanbo…[et al.]. Niobium Uptake and Release by Bacterial Ferric Ion Binding Protein. Bioinorganic Chemistry and Applications No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-462172
American Medical Association (AMA)
Shi, Yanbo& Harvey, Ian& Campopiano, Dominic& Sadler, Peter J.. Niobium Uptake and Release by Bacterial Ferric Ion Binding Protein. Bioinorganic Chemistry and Applications. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-462172
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462172