Immunopathology of Postprimary Tuberculosis : Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions
Joint Authors
Risin, Semyon A.
Hunter, Robert L.
Welsh, Kerry J.
Actor, Jeffrey K.
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Postprimary tuberculosis occurs in immunocompetent people infected with Mycobacterium tuberculosis.
It is restricted to the lung and accounts for 80% of cases and nearly 100% of transmission.
Little is known about the immunopathology of postprimary tuberculosis due to limited availability of specimens.
Tissues from 30 autopsy cases of pulmonary tuberculosis were located.
Sections of characteristic lesions of caseating granulomas, lipid pneumonia, and cavitary stages of postprimary disease were selected for immunohistochemical studies of macrophages, lymphocytes, endothelial cells, and mycobacterial antigens.
A higher percentage of cells in lipid pneumonia (36.1%) and cavitary lesions (27.8%) were positive for the dendritic cell marker DEC-205, compared to granulomas (9.0%, P<.05).
Cavities contained significantly more T-regulatory cells (14.8%) than found in lipid pneumonia (5.2%) or granulomas (4.8%).
Distribution of the immune cell types may contribute to the inability of the immune system to eradicate tuberculosis.
American Psychological Association (APA)
Welsh, Kerry J.& Risin, Semyon A.& Actor, Jeffrey K.& Hunter, Robert L.. 2010. Immunopathology of Postprimary Tuberculosis : Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-462179
Modern Language Association (MLA)
Welsh, Kerry J.…[et al.]. Immunopathology of Postprimary Tuberculosis : Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions. Clinical and Developmental Immunology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-462179
American Medical Association (AMA)
Welsh, Kerry J.& Risin, Semyon A.& Actor, Jeffrey K.& Hunter, Robert L.. Immunopathology of Postprimary Tuberculosis : Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions. Clinical and Developmental Immunology. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-462179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462179