![](/images/graphics-bg.png)
Survival Benefit of Adjuvant Radiation Therapy for Gastric Cancer following Gastrectomy and Extended Lymphadenectomy
Joint Authors
Snyder, R. A.
Phillips, S. E.
Merchant, N. B.
Bailey, C. E.
Chakravarthy, A. B.
Castaldo, E. T.
Source
International Journal of Surgical Oncology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
Although randomized trials suggest a survival benefit of adjuvant chemotherapy and radiation therapy (XRT) for gastric adenocarcinoma, its use in patients who undergo an extended lymphadenectomy is less clear.
The purpose of this study was to determine if a survival benefit exists in gastric cancer patients who receive adjuvant XRT following resection with extended lymphadenectomy.
Methods.
The SEER registry was queried for records of patients with resected gastric adenocarcinoma from 1988 to 2007.
Multivariable Cox regression models were used to assess independent prognostic factors affecting overall survival (OS) and disease-specific survival (DSS).
Results.
Of 15,060 patients identified, 3,208 (21%) received adjuvant XRT.
Adjuvant XRT was independently associated with improved OS (HR 0.67, CI 0.64–0.71) and DSS (HR 0.69, CI 0.65–0.73) in stages IB through IV (M0).
This OS and DSS benefit persisted regardless of the extent of lymphadenectomy.
Furthermore, lymphadenectomy with >25 LN resected was associated with improved OS and DSS compared with <15 LN or 15–25 LN.
Conclusion.
This population-based study shows a survival benefit of adjuvant XRT following gastrectomy that persists in patients who have an extended lymphadenectomy.
Furthermore, removal of >25 LNs results in improved OS and DSS compared with patients who have fewer LNs resected.
American Psychological Association (APA)
Snyder, R. A.& Castaldo, E. T.& Bailey, C. E.& Phillips, S. E.& Chakravarthy, A. B.& Merchant, N. B.. 2012. Survival Benefit of Adjuvant Radiation Therapy for Gastric Cancer following Gastrectomy and Extended Lymphadenectomy. International Journal of Surgical Oncology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-462180
Modern Language Association (MLA)
Snyder, R. A.…[et al.]. Survival Benefit of Adjuvant Radiation Therapy for Gastric Cancer following Gastrectomy and Extended Lymphadenectomy. International Journal of Surgical Oncology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-462180
American Medical Association (AMA)
Snyder, R. A.& Castaldo, E. T.& Bailey, C. E.& Phillips, S. E.& Chakravarthy, A. B.& Merchant, N. B.. Survival Benefit of Adjuvant Radiation Therapy for Gastric Cancer following Gastrectomy and Extended Lymphadenectomy. International Journal of Surgical Oncology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-462180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462180