Cyclin D1 in ASM Cells from Asthmatics Is Insensitive to Corticosteroid Inhibition
Joint Authors
Allen, Jodi C.
Schlosser, Tobias
Ramsay, Emma E.
Ge, Qi
Ammit, Alaina J.
Seidel, Petra
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Hyperplasia of airway smooth muscle (ASM) is a feature of the remodelled airway in asthmatics.
We examined the antiproliferative effectiveness of the corticosteroid dexamethasone on expression of the key regulator of G1 cell cycle progression—cyclin D1—in ASM cells from nonasthmatics and asthmatics stimulated with the mitogen platelet-derived growth factor BB.
While cyclin D1 mRNA and protein expression were repressed in cells from nonasthmatics in contrast, cyclin D1 expression in asthmatics was resistant to inhibition by dexamethasone.
This was independent of a repressive effect on glucocorticoid receptor translocation.
Our results corroborate evidence demonstrating that corticosteroids inhibit mitogen-induced proliferation only in ASM cells from subjects without asthma and suggest that there are corticosteroid-insensitive proliferative pathways in asthmatics.
American Psychological Association (APA)
Allen, Jodi C.& Seidel, Petra& Schlosser, Tobias& Ramsay, Emma E.& Ge, Qi& Ammit, Alaina J.. 2012. Cyclin D1 in ASM Cells from Asthmatics Is Insensitive to Corticosteroid Inhibition. Journal of Allergy،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-462190
Modern Language Association (MLA)
Allen, Jodi C.…[et al.]. Cyclin D1 in ASM Cells from Asthmatics Is Insensitive to Corticosteroid Inhibition. Journal of Allergy No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-462190
American Medical Association (AMA)
Allen, Jodi C.& Seidel, Petra& Schlosser, Tobias& Ramsay, Emma E.& Ge, Qi& Ammit, Alaina J.. Cyclin D1 in ASM Cells from Asthmatics Is Insensitive to Corticosteroid Inhibition. Journal of Allergy. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-462190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462190