Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease
Joint Authors
Fujita, Kyota
Nakabeppu, Yusaku
Noda, Mami
Source
Mathematical Problems in Engineering
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Since the first description of Parkinson's disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symptoms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease.
1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins which produce Parkinsonian pathology.
From the animal studies using these neurotoxins, it has become well established that oxidative stress is a primary cause of, and essential for, cellular apoptosis in dopaminergic neurons.
Here, we describe the mechanism whereby oxidative stress evokes irreversible cell death, and propose a novel therapeutic strategy for PD using molecular hydrogen.
Hydrogen has an ability to reduce oxidative damage and ameliorate the loss of nigrostriatal dopaminergic neuronal pathway in two experimental animal models.
Thus, it is strongly suggested that hydrogen might provide a great advantage to prevent or minimize the onset and progression of PD.
American Psychological Association (APA)
Fujita, Kyota& Nakabeppu, Yusaku& Noda, Mami. 2011. Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease. Mathematical Problems in Engineering،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-462195
Modern Language Association (MLA)
Fujita, Kyota…[et al.]. Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease. Mathematical Problems in Engineering No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-462195
American Medical Association (AMA)
Fujita, Kyota& Nakabeppu, Yusaku& Noda, Mami. Therapeutic Effects of Hydrogen in Animal Models of Parkinson's Disease. Mathematical Problems in Engineering. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-462195
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462195