Optimization of the Preparation Process for an Oral Phytantriol-Based Amphotericin B Cubosomes
Joint Authors
Xu, Yuehong
Tan, Yinhe
Chen, Meiwan
Zhu, Xingqi
Wu, Chuanbin
Yang, Zhiwen
Feng, Min
Peng, Xinsheng
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
In order to develop an oral formation of Amphotericin B (AmB) using phytantriol- (PYT-) based cubosomes with desirable properties, homogenization conditions were firstly investigated to determine their effects on the morphological and dimensional characteristics of cubosomes.
Under the optimized homogenization conditions of 1200 bar for 9 cycles, cubosomes with reproducible, narrow particle size distribution and a mean particle size of 256.9 nm ± 4.9 nm were obtained.
The structure of the dispersed cubosomes was revealed by SAXS (small-angle X-ray scattering) and Cryo-TEM (cryogenic transmission electron microscopy) as a bicontinuous cubic liquid crystalline phase with Pn3m geometry.
To overcome the poor drug solubility and increase the drug-loading rate, a solubilization method was firstly used to develop cubosomes containing AmB.
The encapsulation efficiency determined by HPLC assay was 87.8%±3.4%, and UV spectroscopy and stability studies in simulated gastric fluids further confirmed that AmB was successfully encapsulated in cubosomes.
American Psychological Association (APA)
Yang, Zhiwen& Peng, Xinsheng& Tan, Yinhe& Chen, Meiwan& Zhu, Xingqi& Feng, Min…[et al.]. 2011. Optimization of the Preparation Process for an Oral Phytantriol-Based Amphotericin B Cubosomes. Journal of Nanomaterials،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-462210
Modern Language Association (MLA)
Yang, Zhiwen…[et al.]. Optimization of the Preparation Process for an Oral Phytantriol-Based Amphotericin B Cubosomes. Journal of Nanomaterials No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-462210
American Medical Association (AMA)
Yang, Zhiwen& Peng, Xinsheng& Tan, Yinhe& Chen, Meiwan& Zhu, Xingqi& Feng, Min…[et al.]. Optimization of the Preparation Process for an Oral Phytantriol-Based Amphotericin B Cubosomes. Journal of Nanomaterials. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-462210
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462210
