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Analysis of Clinical Outcome of Patients with Poorly Differentiated Thyroid Carcinoma
Joint Authors
Sonoo, Hiroshi
Kurebayashi, Junichi
Ohta, Yusuke
Yamamoto, Yutaka
Tanaka, Katsuhiro
Sohda, Mai
Saito, Wataru
Shimo, Toshiro
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
We retrospectively analyzed whether poor differentiation is the independent prognostic factor for thyroid carcinoma or not.
Methods.
The subjects were 29 patients with PDTC who were treated between April 1996 and March 2006 to compare with those of well-differentiated papillary carcinoma patients (n=227).
Results.
The relapse free (RFS), distant relapse-free survival and cause-specific survival, rates were significantly lower in patients with PDTC (P<.0001, P<.001, and P<.05).
After classification into focal (<10%) and diffuse type (over 10%) of PDTC, there were no significant differences in RFS and cause-specific survival due to component type or proportion of poorly differentiated component.
On multivariate analysis, poor differentiation (P<.0005, RR = 4.456, 95% CI; 1.953–10.167) and extrathyroidal infiltration (P<.05, RR = 2.898, 95% CI; 1.278–6.572) showed a significant impact on DFS, and poor differentiation (P<.05, RR = 9.343, 1.314–66.453) and age (P<.005, RR = 1.306, 1.103–1.547) significantly impacted cause-specific survival.
Conclusion.
Poor differentiation was an independent factor for survival.
Distant relapse was significantly more common among PDTC patients, and systemic therapy might be warranted.
American Psychological Association (APA)
Tanaka, Katsuhiro& Sonoo, Hiroshi& Saito, Wataru& Ohta, Yusuke& Shimo, Toshiro& Sohda, Mai…[et al.]. 2011. Analysis of Clinical Outcome of Patients with Poorly Differentiated Thyroid Carcinoma. ISRN Endocrinology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-462214
Modern Language Association (MLA)
Tanaka, Katsuhiro…[et al.]. Analysis of Clinical Outcome of Patients with Poorly Differentiated Thyroid Carcinoma. ISRN Endocrinology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-462214
American Medical Association (AMA)
Tanaka, Katsuhiro& Sonoo, Hiroshi& Saito, Wataru& Ohta, Yusuke& Shimo, Toshiro& Sohda, Mai…[et al.]. Analysis of Clinical Outcome of Patients with Poorly Differentiated Thyroid Carcinoma. ISRN Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-462214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462214