New Kinetic Spectrophotometric Method for Determination of Fexofenadine Hydrochloride in Pharmaceutical Formulations
Joint Authors
Khateeb, Mouhammed
Ashour, Safwan
Source
International Journal of Spectroscopy
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A simple and sensitive kinetic spectrophotometric method was developed for the determination of fexofenadine hydrochloride in bulk and pharmaceutical preparations.
The method is based on a kinetic investigation of the oxidation reaction of fexofenadine using alkaline potassium permanganate as an oxidizing agent at room temperature.
The reaction is followed spectrophotometrically by measuring the increase of absorbance owing to the formation of manganate ion at 610 nm.
The initial rate and fixed time (at 15 min) methods are utilized for construction of calibration graphs.
All the reaction conditions for the proposed method have been studied.
The linearity range was found to be 2.5–50.0 μg mL−1 with detection limit of 0.055 μg mL−1 for both initial rate and fixed time methods.
The proposed method was applied successfully for the determination of fexofenadine in pharmaceutical formulations; the percentage recoveries were 99.98–101.96%.
The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy and precision.
American Psychological Association (APA)
Ashour, Safwan& Khateeb, Mouhammed. 2014. New Kinetic Spectrophotometric Method for Determination of Fexofenadine Hydrochloride in Pharmaceutical Formulations. International Journal of Spectroscopy،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-462224
Modern Language Association (MLA)
Ashour, Safwan& Khateeb, Mouhammed. New Kinetic Spectrophotometric Method for Determination of Fexofenadine Hydrochloride in Pharmaceutical Formulations. International Journal of Spectroscopy No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-462224
American Medical Association (AMA)
Ashour, Safwan& Khateeb, Mouhammed. New Kinetic Spectrophotometric Method for Determination of Fexofenadine Hydrochloride in Pharmaceutical Formulations. International Journal of Spectroscopy. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-462224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462224