Taxpas : Epidemiological and Survival Data in Breast Cancer Patients Treated with a Docetaxel-Based Chemotherapy Regimen in South Africa

Abstract EN

Breast cancer is the leading cancer among South African women.

There is limited South African epidemiological data on triple-negative breast cancer (TNBC).

Taxpas was a nonrandomized observational survey conducted in multiple centres in South Africa from April 2004 to December 2010.

1632 female patients diagnosed with breast cancer, with a median age of 51 years, were enrolled in the survey.

Patients were treated on a docetaxel-based chemotherapy regimen.

The objective of the study was to assess epidemiological data and survival data.

The incidence of TNBC was 14%.

The one-year survival rate for the total cohort was 84%.

The one-year survival rate for patients with early stage and metastatic breast cancer was recorded as 94% and 65%, respectively.

Patients with TNBC stage III (all ages) and stage IV (≤50 years) had statistically significant worse 1-year survival rate compared to N-TNBC patients of the same age and stages.

Conclusion.

The incidence of TNBC in South Africa which is 14% is comparable to global incidence.

The 1-year survival data for certain subgroups supports the literature saying that TNBC carries a worse prognosis compared to N-TNBC.

Women ≤50 years diagnosed with late stage TNBC carried the worst prognosis in this survey.