The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population
Joint Authors
Zhang, Yusi
Zhang, Yun
Jin, Boquan
Wang, Jiuping
Ma, Ying
Wei, Chao
Yang, Angang
Yuan, Bin
Xu, Zhuwei
Zhang, Chunmei
Zhuang, Ran
Liu, Bei
Yi, Jing
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The polymorphism of human leukocyte antigen (HLA), which is a genetic factor that influences the progression of hemorrhagic fever with renal syndrome (HFRS) after Hantaan virus (HTNV) infection, was incompletely understood.
In this case-control study, 76 HFRS patients and 370 healthy controls of the Chinese Han population were typed for the HLA-A, -B, and -DRB1 loci.
The general variation at the HLA-DRB1 locus was associated with the onset of HFRS (P<0.05).
The increasing frequencies of HLA-DRB1*09 and HLA-B*46-DRB1*09 in HFRS patients were observed as reproducing a previous study.
Moreover, the HLA-B*51-DRB1*09 was susceptible to HFRS (P=0.037; OR =3.62; 95% CI: 1.00–13.18).
The increasing frequencies of HLA-B*46, HLA-B*46-DRB1*09, and HLA-B*51-DRB1*09 were observed almost in severe/critical HFRS patients.
The mean level of maximum serum creatinine was higher in HLA-B*46-DRB1*09 (P=0.011), HLA-B*51-DRB1*09 (P=0.041), or HLA-B*46 (P=0.011) positive patients than that in the negative patients.
These findings suggest that the allele HLA-B*46 and haplotypes HLA-B*46-DRB1*09 and HLA-B*51-DRB1*09 in patients could contribute to a more severe degree of HFRS and more serious kidney injury, which improve our understanding of the HLA polymorphism for a different outcome of HTNV infection.
American Psychological Association (APA)
Ma, Ying& Yuan, Bin& Yi, Jing& Zhuang, Ran& Wang, Jiuping& Zhang, Yun…[et al.]. 2012. The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-462238
Modern Language Association (MLA)
Ma, Ying…[et al.]. The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population. Clinical and Developmental Immunology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-462238
American Medical Association (AMA)
Ma, Ying& Yuan, Bin& Yi, Jing& Zhuang, Ran& Wang, Jiuping& Zhang, Yun…[et al.]. The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-462238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462238